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NUP98

GENERAL INFORMATION

Gene name

 NUP98

Gene description

 Nucleoporin 98kDa

Protein class

 Cancer-related genes
Disease related genes
Enzymes
Plasma proteins
Potential drug targets
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 10
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

DATA RELIABILITY

Reliability score

 Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
N/A
Hippocampus
N/A
N/A
Caudate
N/A
N/A
Cerebellum
N/A
N/A
Endocrine tissues
N/A
Bone marrow & immune system
N/A
Appendix
N/A
Tonsil
N/A
Spleen
N/A
Muscle tissues
N/A
Lung
N/A
Nasopharynx
N/A
N/A
Bronchus
N/A
N/A
Lung
N/A
Liver & gallbladder
N/A
Liver
N/A
Pancreas
N/A
Pancreas
N/A
Gastrointestinal tract
N/A
Oral mucosa
N/A
N/A
Esophagus
N/A
Stomach
N/A
Duodenum
N/A
Colon
N/A
Rectum
N/A
Kidney & urinary bladder
N/A
Kidney
N/A
Male tissues
N/A
Testis
N/A
Prostate
N/A
Female tissues
N/A
Breast
N/A
Vagina
N/A
N/A
Ovary
N/A
Placenta
N/A
Adipose & soft tissue
N/A
Soft tissue
N/A
N/A
Skin
N/A
Skin
N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 NUP98 (HGNC Symbol)

Synonyms

 NUP96

Description

 Nucleoporin 98kDa (HGNC Symbol)

Entrez gene summary

 Signal-mediated nuclear import and export proceed through the nuclear pore complex (NPC), which is comprised of approximately 50 unique proteins collectively known as nucleoporins. The 98 kDa nucleoporin is generated through a biogenesis pathway that involves synthesis and proteolytic cleavage of a 186 kDa precursor protein. This cleavage results in the 98 kDa nucleoporin as well as a 96 kDa nucleoporin, both of which are localized to the nucleoplasmic side of the NPC. Rat studies show that the 98 kDa nucleoporin functions as one of several docking site nucleoporins of transport substrates. The human gene has been shown to fuse to several genes following chromosome translocations in acute myelogenous leukemia (AML) and T-cell acute lymphocytic leukemia (T-ALL). This gene is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. Alternative splicing of this gene results in several transcript variants; however, not all variants have been fully described. [provided by RefSeq, May 2010]

Chromosome

 11

Cytoband

 p15.4

Chromosome location (bp)

 3671083 - 3797792

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000110713 (version 83.38)

Entrez gene

 4928

UniProt

 P52948 (UniProt - Evidence at protein level)

neXtProt

 NX_P52948

Antibodypedia

 NUP98 antibodies

PROTEIN BROWSER
NUP98-001
NUP98-002
NUP98-003
NUP98-004
NUP98-012
NUP98-013
NUP98-017
NUP98-019
NUP98-020
NUP98-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
NUP98-001
ENSP00000316032
ENST00000324932
P52948 [Direct mapping]
Nuclear pore complex protein Nup98-Nup96 Nuclear pore complex protein Nup98 Nuclear pore complex protein Nup96
Show all
Enzymes
   Peptidases
   Serine-type peptidases
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000059 [protein import into nucleus, docking]
GO:0000278 [mitotic cell cycle]
GO:0000776 [kinetochore]
GO:0005215 [transporter activity]
GO:0005515 [protein binding]
GO:0005635 [nuclear envelope]
GO:0005643 [nuclear pore]
GO:0005654 [nucleoplasm]
GO:0005829 [cytosol]
GO:0005975 [carbohydrate metabolic process]
GO:0006260 [DNA replication]
GO:0006810 [transport]
GO:0006913 [nucleocytoplasmic transport]
GO:0006999 [nuclear pore organization]
GO:0007077 [mitotic nuclear envelope disassembly]
GO:0007264 [small GTPase mediated signal transduction]
GO:0008033 [tRNA processing]
GO:0008139 [nuclear localization sequence binding]
GO:0008645 [hexose transport]
GO:0010467 [gene expression]
GO:0010827 [regulation of glucose transport]
GO:0015758 [glucose transport]
GO:0016032 [viral process]
GO:0016925 [protein sumoylation]
GO:0017056 [structural constituent of nuclear pore]
GO:0019048 [modulation by virus of host morphology or physiology]
GO:0019054 [modulation by virus of host process]
GO:0019058 [viral life cycle]
GO:0019083 [viral transcription]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0031047 [gene silencing by RNA]
GO:0031080 [nuclear pore outer ring]
GO:0031965 [nuclear membrane]
GO:0034399 [nuclear periphery]
GO:0034605 [cellular response to heat]
GO:0042277 [peptide binding]
GO:0042405 [nuclear inclusion body]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0044615 [nuclear pore nuclear basket]
GO:0051028 [mRNA transport]
GO:0051292 [nuclear pore complex assembly]
GO:0055085 [transmembrane transport]
GO:1900034 [regulation of cellular response to heat]
Show all
 1800 aa
195.8 kDa 		No 0
NUP98-002
ENSP00000380199
ENST00000397004
P52948 [Direct mapping]
Nuclear pore complex protein Nup98-Nup96 Nuclear pore complex protein Nup98 Nuclear pore complex protein Nup96
Show all
Enzymes
   Peptidases
   Serine-type peptidases
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000059 [protein import into nucleus, docking]
GO:0000278 [mitotic cell cycle]
GO:0000776 [kinetochore]
GO:0005215 [transporter activity]
GO:0005515 [protein binding]
GO:0005635 [nuclear envelope]
GO:0005643 [nuclear pore]
GO:0005654 [nucleoplasm]
GO:0005829 [cytosol]
GO:0005975 [carbohydrate metabolic process]
GO:0006260 [DNA replication]
GO:0006810 [transport]
GO:0006913 [nucleocytoplasmic transport]
GO:0006999 [nuclear pore organization]
GO:0007077 [mitotic nuclear envelope disassembly]
GO:0007264 [small GTPase mediated signal transduction]
GO:0008033 [tRNA processing]
GO:0008645 [hexose transport]
GO:0010467 [gene expression]
GO:0010827 [regulation of glucose transport]
GO:0015758 [glucose transport]
GO:0016032 [viral process]
GO:0016925 [protein sumoylation]
GO:0017056 [structural constituent of nuclear pore]
GO:0019048 [modulation by virus of host morphology or physiology]
GO:0019054 [modulation by virus of host process]
GO:0019058 [viral life cycle]
GO:0019083 [viral transcription]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0031047 [gene silencing by RNA]
GO:0031080 [nuclear pore outer ring]
GO:0031965 [nuclear membrane]
GO:0034399 [nuclear periphery]
GO:0034605 [cellular response to heat]
GO:0042405 [nuclear inclusion body]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0044615 [nuclear pore nuclear basket]
GO:0051028 [mRNA transport]
GO:0051292 [nuclear pore complex assembly]
GO:0055085 [transmembrane transport]
GO:1900034 [regulation of cellular response to heat]
Show all
 920 aa
96.1 kDa 		No 0
NUP98-003
ENSP00000413146
ENST00000429801
H7C3P6 [Direct mapping]
Nuclear pore complex protein Nup98-Nup96
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
 753 aa
85.7 kDa 		No 0
NUP98-004
ENSP00000380202
ENST00000397007
P52948 [Direct mapping]
Nuclear pore complex protein Nup98-Nup96 Nuclear pore complex protein Nup98 Nuclear pore complex protein Nup96
Show all
Enzymes
   Peptidases
   Serine-type peptidases
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000059 [protein import into nucleus, docking]
GO:0000278 [mitotic cell cycle]
GO:0000776 [kinetochore]
GO:0005215 [transporter activity]
GO:0005515 [protein binding]
GO:0005635 [nuclear envelope]
GO:0005643 [nuclear pore]
GO:0005654 [nucleoplasm]
GO:0005829 [cytosol]
GO:0005975 [carbohydrate metabolic process]
GO:0006260 [DNA replication]
GO:0006810 [transport]
GO:0006913 [nucleocytoplasmic transport]
GO:0006999 [nuclear pore organization]
GO:0007077 [mitotic nuclear envelope disassembly]
GO:0007264 [small GTPase mediated signal transduction]
GO:0008033 [tRNA processing]
GO:0008645 [hexose transport]
GO:0010467 [gene expression]
GO:0010827 [regulation of glucose transport]
GO:0015758 [glucose transport]
GO:0016032 [viral process]
GO:0016925 [protein sumoylation]
GO:0017056 [structural constituent of nuclear pore]
GO:0019048 [modulation by virus of host morphology or physiology]
GO:0019054 [modulation by virus of host process]
GO:0019058 [viral life cycle]
GO:0019083 [viral transcription]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0031047 [gene silencing by RNA]
GO:0031080 [nuclear pore outer ring]
GO:0031965 [nuclear membrane]
GO:0034399 [nuclear periphery]
GO:0034605 [cellular response to heat]
GO:0042405 [nuclear inclusion body]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0044615 [nuclear pore nuclear basket]
GO:0051028 [mRNA transport]
GO:0051292 [nuclear pore complex assembly]
GO:0055085 [transmembrane transport]
GO:1900034 [regulation of cellular response to heat]
Show all
 937 aa
97.8 kDa 		No 0
NUP98-012
ENSP00000434698
ENST00000532475
E9PNN0 [Direct mapping]
Nuclear pore complex protein Nup98-Nup96
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
 124 aa
11.9 kDa 		No 0
NUP98-013
ENSP00000347404
ENST00000355260
P52948 [Direct mapping]
Nuclear pore complex protein Nup98-Nup96 Nuclear pore complex protein Nup98 Nuclear pore complex protein Nup96
Show all
Enzymes
   Peptidases
   Serine-type peptidases
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000059 [protein import into nucleus, docking]
GO:0000278 [mitotic cell cycle]
GO:0000776 [kinetochore]
GO:0005215 [transporter activity]
GO:0005515 [protein binding]
GO:0005635 [nuclear envelope]
GO:0005643 [nuclear pore]
GO:0005654 [nucleoplasm]
GO:0005829 [cytosol]
GO:0005975 [carbohydrate metabolic process]
GO:0006260 [DNA replication]
GO:0006810 [transport]
GO:0006913 [nucleocytoplasmic transport]
GO:0006999 [nuclear pore organization]
GO:0007077 [mitotic nuclear envelope disassembly]
GO:0007264 [small GTPase mediated signal transduction]
GO:0008033 [tRNA processing]
GO:0008645 [hexose transport]
GO:0010467 [gene expression]
GO:0010827 [regulation of glucose transport]
GO:0015758 [glucose transport]
GO:0016032 [viral process]
GO:0016925 [protein sumoylation]
GO:0017056 [structural constituent of nuclear pore]
GO:0019048 [modulation by virus of host morphology or physiology]
GO:0019054 [modulation by virus of host process]
GO:0019058 [viral life cycle]
GO:0019083 [viral transcription]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0031047 [gene silencing by RNA]
GO:0031080 [nuclear pore outer ring]
GO:0031965 [nuclear membrane]
GO:0034399 [nuclear periphery]
GO:0034605 [cellular response to heat]
GO:0042405 [nuclear inclusion body]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0044615 [nuclear pore nuclear basket]
GO:0051028 [mRNA transport]
GO:0051292 [nuclear pore complex assembly]
GO:0055085 [transmembrane transport]
GO:1900034 [regulation of cellular response to heat]
Show all
 1726 aa
187.2 kDa 		No 0
NUP98-017
ENSP00000432142
ENST00000529379
H0YCR0 [Direct mapping]
Nuclear pore complex protein Nup98-Nup96
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
 179 aa
18.4 kDa 		No 0
NUP98-019
ENSP00000436226
ENST00000527104
H0YEN4 [Direct mapping]
Nuclear pore complex protein Nup98-Nup96
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
 235 aa
24.1 kDa 		No 0
NUP98-020
ENSP00000432275
ENST00000533346
H0YCT1 [Direct mapping]
Nuclear pore complex protein Nup98-Nup96
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
 93 aa
10.5 kDa 		No 0
NUP98-201
ENSP00000352091
ENST00000359171
P52948 [Direct mapping]
Nuclear pore complex protein Nup98-Nup96 Nuclear pore complex protein Nup98 Nuclear pore complex protein Nup96
Show all
Enzymes
   Peptidases
   Serine-type peptidases
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000059 [protein import into nucleus, docking]
GO:0000278 [mitotic cell cycle]
GO:0000776 [kinetochore]
GO:0005215 [transporter activity]
GO:0005515 [protein binding]
GO:0005635 [nuclear envelope]
GO:0005643 [nuclear pore]
GO:0005654 [nucleoplasm]
GO:0005829 [cytosol]
GO:0005975 [carbohydrate metabolic process]
GO:0006260 [DNA replication]
GO:0006810 [transport]
GO:0006913 [nucleocytoplasmic transport]
GO:0006999 [nuclear pore organization]
GO:0007077 [mitotic nuclear envelope disassembly]
GO:0007264 [small GTPase mediated signal transduction]
GO:0008033 [tRNA processing]
GO:0008645 [hexose transport]
GO:0010467 [gene expression]
GO:0010827 [regulation of glucose transport]
GO:0015758 [glucose transport]
GO:0016032 [viral process]
GO:0016925 [protein sumoylation]
GO:0017056 [structural constituent of nuclear pore]
GO:0019048 [modulation by virus of host morphology or physiology]
GO:0019054 [modulation by virus of host process]
GO:0019058 [viral life cycle]
GO:0019083 [viral transcription]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0031047 [gene silencing by RNA]
GO:0031080 [nuclear pore outer ring]
GO:0031965 [nuclear membrane]
GO:0034399 [nuclear periphery]
GO:0034605 [cellular response to heat]
GO:0042405 [nuclear inclusion body]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0044615 [nuclear pore nuclear basket]
GO:0051028 [mRNA transport]
GO:0051292 [nuclear pore complex assembly]
GO:0055085 [transmembrane transport]
GO:1900034 [regulation of cellular response to heat]
Show all
 1817 aa
197.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.