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Distinct positivity was observed tumor stroma. A few renal cancers displayed moderate cytoplasmic immunoreactivity. Remaining malignant cells were negative.
Strong cytoplasmic or membranous staining of blood vessels in most cancer tissues. Cancer cells were negative.
GENE INFORMATION
Gene name
VWF (HGNC Symbol)
Synonyms
F8VWF
Description
Von Willebrand factor (HGNC Symbol)
Entrez gene summary
This gene encodes a glycoprotein involved in hemostasis. The encoded preproprotein is proteolytically processed following assembly into large multimeric complexes. These complexes function in the adhesion of platelets to sites of vascular injury and the transport of various proteins in the blood. Mutations in this gene result in von Willebrand disease, an inherited bleeding disorder. An unprocessed pseudogene has been found on chromosome 22. [provided by RefSeq, Oct 2015]
P04275 [Direct mapping] von Willebrand factor von Willebrand antigen 2
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Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Candidate cardiovascular disease genes Disease related genes FDA approved drug targets Biotech drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)