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P3H3

CANCER ATLAS

Gene description

 Prolyl 3-hydroxylase 3

Protein class

 Enzymes, Predicted secreted proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY
HPA043695

GENE INFORMATION

Gene name

 P3H3 (HGNC Symbol)

Synonyms

 GRCB, HSU47926, LEPREL2

Description

 Prolyl 3-hydroxylase 3 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene belongs to the leprecan family of proteoglycans, which function as collagen prolyl hydroxylases that are required for proper collagen biosynthesis, folding and assembly. This protein, like other family members, is thought to reside in the endoplasmic reticulum. Epigenetic inactivation of this gene is associated with breast and other cancers, suggesting that it may function as a tumor suppressor. [provided by RefSeq, Aug 2013]

Chromosome

 12

Cytoband

 p13.31

Chromosome location (bp)

 6828410 - 6839851

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000110811 (version 83.38)

Entrez gene

 10536

UniProt

 Q8IVL6 (UniProt - Evidence at protein level)

neXtProt

 NX_Q8IVL6

Antibodypedia

 P3H3 antibodies

PROTEIN BROWSER
P3H3-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
P3H3-002
ENSP00000478600
ENST00000290510
Q8IVL6 [Direct mapping]
Prolyl 3-hydroxylase 3
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Enzymes
   ENZYME proteins
   Oxidoreductases
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005506 [iron ion binding]
GO:0005788 [endoplasmic reticulum lumen]
GO:0008285 [negative regulation of cell proliferation]
GO:0016491 [oxidoreductase activity]
GO:0016705 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen]
GO:0019511 [peptidyl-proline hydroxylation]
GO:0019797 [procollagen-proline 3-dioxygenase activity]
GO:0030198 [extracellular matrix organization]
GO:0031418 [L-ascorbic acid binding]
GO:0055114 [oxidation-reduction process]
Show all
 736 aa
81.8 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.