Expression of PRDM4 in cancer - Summary

CANCER ATLAS

Gene description

PR domain containing 4

Protein class

Predicted intracellular proteins, Transcription factors

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA024322

GENE INFORMATION
Gene name	PRDM4 (HGNC Symbol)
Synonyms	PFM1
Description	PR domain containing 4 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a transcription factor of the PR-domain protein family. It contains a PR-domain and multiple zinc finger motifs. Transcription factors of the PR-domain family are known to be involved in cell differentiation and tumorigenesis. An elevated expression level of this gene has been observed in PC12 cells treated with nerve growth factor, beta polypeptide (NGF). This gene is located in a chromosomal region that is thought to contain tumor suppressor genes. [provided by RefSeq, Jul 2008]
Chromosome	12
Cytoband	q23.3
Chromosome location (bp)	107732866 - 107761272
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000110851 (version 83.38)
Entrez gene	11108
UniProt	Q9UKN5 (UniProt - Evidence at protein level)
neXtProt	NX_Q9UKN5
Antibodypedia	PRDM4 antibodies

PROTEIN BROWSER

PRDM4-001	PRDM4-004	PRDM4-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PRDM4-001 ENSP00000228437 ENST00000228437	Q9UKN5 [Direct mapping] PR domain zinc finger protein 4 A0A024RBM7 [Target identity:100%; Query identity:100%] PR domain zinc finger protein 4 Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Show all	GO:0003677 [DNA binding] GO:0005123 [death receptor binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0006355 [regulation of transcription, DNA-templated] GO:0006366 [transcription from RNA polymerase II promoter] GO:0007165 [signal transduction] GO:0008168 [methyltransferase activity] GO:0008270 [zinc ion binding] GO:0008283 [cell proliferation] GO:0030308 [negative regulation of cell growth] GO:0031670 [cellular response to nutrient] GO:0035097 [histone methyltransferase complex] GO:0043985 [histone H4-R3 methylation] GO:0045786 [negative regulation of cell cycle] GO:0046872 [metal ion binding] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0071363 [cellular response to growth factor stimulus] GO:1990226 [histone methyltransferase binding] Show all	801 aa 87.9 kDa	No	0
PRDM4-004 ENSP00000448684 ENST00000547188	F8VRG2 [Direct mapping] PR domain zinc finger protein 4 Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Show all		75 aa 7.6 kDa	No	0
PRDM4-005 ENSP00000449295 ENST00000550659	H0YIF6 [Direct mapping] PR domain zinc finger protein 4 Show all	Predicted intracellular proteins Show all	GO:0005515 [protein binding] Show all	279 aa 30.6 kDa	No	0