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METAP2

CANCER ATLAS

Gene description

 Methionyl aminopeptidase 2

Protein class

 Enzymes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA019095
CAB013025

GENE INFORMATION

Gene name

 METAP2 (HGNC Symbol)

Synonyms

 MAP2, MNPEP, p67

Description

 Methionyl aminopeptidase 2 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a member of the methionyl aminopeptidase family. The encoded protein functions both by protecting the alpha subunit of eukaryotic initiation factor 2 from inhibitory phosphorylation and by removing the amino-terminal methionine residue from nascent proteins. Increased expression of this gene is associated with various forms of cancer, and the anti-cancer drugs fumagillin and ovalicin inhibit the protein by irreversibly binding to its active site. Inhibitors of this gene have also been shown to be effective for the treatment of obesity. A pseudogene of this gene is located on chromosome 2. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]

Chromosome

 12

Cytoband

 q22

Chromosome location (bp)

 95473520 - 95515839

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000111142 (version 83.38)

Entrez gene

 10988

UniProt

 P50579 (UniProt - Evidence at protein level)

neXtProt

 NX_P50579

Antibodypedia

 METAP2 antibodies

PROTEIN BROWSER
METAP2-001
METAP2-002
METAP2-004
METAP2-006
METAP2-007
METAP2-008
METAP2-010
METAP2-012

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
METAP2-001
ENSP00000325312
ENST00000323666
P50579 [Direct mapping]
Methionine aminopeptidase 2
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Metallopeptidases
Predicted intracellular proteins
Plasma proteins
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004177 [aminopeptidase activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006508 [proteolysis]
GO:0007603 [phototransduction, visible light]
GO:0008235 [metalloexopeptidase activity]
GO:0016056 [rhodopsin mediated signaling pathway]
GO:0016485 [protein processing]
GO:0018206 [peptidyl-methionine modification]
GO:0022400 [regulation of rhodopsin mediated signaling pathway]
GO:0031365 [N-terminal protein amino acid modification]
GO:0044822 [poly(A) RNA binding]
GO:0046872 [metal ion binding]
GO:0070006 [metalloaminopeptidase activity]
GO:0070084 [protein initiator methionine removal]
Show all
 478 aa
52.9 kDa 		No 0
METAP2-002
ENSP00000261220
ENST00000261220
P50579 [Direct mapping]
Methionine aminopeptidase 2
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Metallopeptidases
Predicted intracellular proteins
Plasma proteins
FDA approved drug targets
   Small molecule drugs
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004177 [aminopeptidase activity]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006508 [proteolysis]
GO:0007603 [phototransduction, visible light]
GO:0008235 [metalloexopeptidase activity]
GO:0016056 [rhodopsin mediated signaling pathway]
GO:0016485 [protein processing]
GO:0018206 [peptidyl-methionine modification]
GO:0022400 [regulation of rhodopsin mediated signaling pathway]
GO:0031365 [N-terminal protein amino acid modification]
GO:0044822 [poly(A) RNA binding]
GO:0046872 [metal ion binding]
GO:0070006 [metalloaminopeptidase activity]
GO:0070084 [protein initiator methionine removal]
Show all
 455 aa
50.5 kDa 		No 0
METAP2-004
ENSP00000448169
ENST00000546753
P50579 [Direct mapping]
Methionine aminopeptidase 2
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Metallopeptidases
Predicted intracellular proteins
Plasma proteins
FDA approved drug targets
   Small molecule drugs
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004177 [aminopeptidase activity]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006508 [proteolysis]
GO:0007603 [phototransduction, visible light]
GO:0008235 [metalloexopeptidase activity]
GO:0016056 [rhodopsin mediated signaling pathway]
GO:0016485 [protein processing]
GO:0018206 [peptidyl-methionine modification]
GO:0022400 [regulation of rhodopsin mediated signaling pathway]
GO:0031365 [N-terminal protein amino acid modification]
GO:0044822 [poly(A) RNA binding]
GO:0046872 [metal ion binding]
GO:0070006 [metalloaminopeptidase activity]
GO:0070084 [protein initiator methionine removal]
Show all
 455 aa
50.5 kDa 		No 0
METAP2-006
ENSP00000448614
ENST00000550777
F8VRR3 [Direct mapping]
Methionine aminopeptidase 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004177 [aminopeptidase activity]
GO:0005737 [cytoplasm]
GO:0006508 [proteolysis]
GO:0008235 [metalloexopeptidase activity]
GO:0046872 [metal ion binding]
GO:0070006 [metalloaminopeptidase activity]
GO:0070084 [protein initiator methionine removal]
Show all
 442 aa
48.9 kDa 		No 0
METAP2-007
ENSP00000450063
ENST00000551840
F8VQZ7 [Direct mapping]
Methionine aminopeptidase 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004177 [aminopeptidase activity]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0006508 [proteolysis]
GO:0008235 [metalloexopeptidase activity]
GO:0046872 [metal ion binding]
GO:0070006 [metalloaminopeptidase activity]
GO:0070084 [protein initiator methionine removal]
Show all
 477 aa
52.8 kDa 		No 0
METAP2-008
ENSP00000448370
ENST00000549502
F8VSC4 [Direct mapping]
Methionine aminopeptidase 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 161 aa
17.1 kDa 		No 0
METAP2-010
ENSP00000447661
ENST00000549808
F8VZX9 [Direct mapping]
Methionine aminopeptidase 2
Show all
   Phobius predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004177 [aminopeptidase activity]
GO:0006508 [proteolysis]
GO:0008235 [metalloexopeptidase activity]
Show all
 163 aa
18.1 kDa 		No 0
METAP2-012
ENSP00000449004
ENST00000553151
F8VY03 [Direct mapping]
Methionine aminopeptidase 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004177 [aminopeptidase activity]
GO:0006508 [proteolysis]
GO:0008235 [metalloexopeptidase activity]
Show all
 178 aa
19.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.