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Malignant cells showed moderate cytoplasmic and occasional membranous staining. Several cases of hepatocellular carcinomas, malignant gliomas, lymphomas, carcinoids along with occasional cases of prostate, ovarian, endometrial, urothelial and pancreatic cancers exhibited strong positivity.
GENE INFORMATION
Gene name
CUX2 (HGNC Symbol)
Synonyms
CDP2, CUTL2, KIAA0293
Description
Cut-like homeobox 2 (HGNC Symbol)
Entrez gene summary
This gene encodes a protein which contains three CUT domains and a homeodomain; both domains are DNA-binding motifs. A similar gene, whose gene product possesses different DNA-binding activities, is located on chromosome on chromosome 7. Two pseudogenes of this gene have been identified on chromosomes 10 and 4. [provided by RefSeq, Jan 2013]
O14529 [Direct mapping] Homeobox protein cut-like 2
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Predicted intracellular proteins Plasma proteins Transcription factors Helix-turn-helix domains Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding] GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0001078 [transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding] GO:0003677 [DNA binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0007614 [short-term memory] GO:0010628 [positive regulation of gene expression] GO:0043565 [sequence-specific DNA binding] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0050775 [positive regulation of dendrite morphogenesis] GO:0050890 [cognition] GO:0051965 [positive regulation of synapse assembly] GO:0061003 [positive regulation of dendritic spine morphogenesis] GO:0070062 [extracellular exosome] GO:0071310 [cellular response to organic substance] GO:2000463 [positive regulation of excitatory postsynaptic potential]
