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Most malignant cells displayed moderate to strong cytoplasmic and/or nuclear membranous staining. A majority of malignant lymphomas, hepatocellular carcinomas, lung and prostate cancers were weakly stained or negative.
GENE INFORMATION
Gene name
SH2B3 (HGNC Symbol)
Synonyms
IDDM20, LNK
Description
SH2B adaptor protein 3 (HGNC Symbol)
Entrez gene summary
This gene encodes a member of the SH2B adaptor family of proteins, which are involved in a range of signaling activities by growth factor and cytokine receptors. The encoded protein is a key negative regulator of cytokine signaling and plays a critical role in hematopoiesis. Mutations in this gene have been associated with susceptibility to celiac disease type 13 and susceptibility to insulin-dependent diabetes mellitus. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2014]
Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
