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AKAP3

CANCER ATLAS

Gene description

 A kinase (PRKA) anchor protein 3

Protein class

 Predicted intracellular proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA039765

GENE INFORMATION

Gene name

 AKAP3 (HGNC Symbol)

Synonyms

 AKAP110, CT82, FSP95, SOB1

Description

 A kinase (PRKA) anchor protein 3 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of A-kinase anchoring proteins (AKAPs), a family of functionally related proteins that target protein kinase A to discrete locations within the cell. The encoded protein is reported to participate in protein-protein interactions with the R-subunit of the protein kinase A as well as sperm-associated proteins. This protein is expressed in spermatozoa and localized to the acrosomal region of the sperm head as well as the length of the principal piece. It may function as a regulator of motility, capacitation, and the acrosome reaction. [provided by RefSeq, May 2013]

Chromosome

 12

Cytoband

 p13.32

Chromosome location (bp)

 4615508 - 4649047

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000111254 (version 83.38)

Entrez gene

 10566

UniProt

 O75969 (UniProt - Evidence at protein level)

neXtProt

 NX_O75969

Antibodypedia

 AKAP3 antibodies

PROTEIN BROWSER
AKAP3-001
AKAP3-002
AKAP3-004
AKAP3-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
AKAP3-001
ENSP00000440994
ENST00000545990
O75969 [Direct mapping]
A-kinase anchor protein 3
V9HWD4 [Target identity:100%; Query identity:100%]
Epididymis luminal protein 159
Show all
Predicted intracellular proteins
Show all
GO:0001669 [acrosomal vesicle]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006928 [movement of cell or subcellular component]
GO:0007338 [single fertilization]
GO:0007340 [acrosome reaction]
GO:0010738 [regulation of protein kinase A signaling]
GO:0035686 [sperm fibrous sheath]
GO:0097228 [sperm principal piece]
Show all
 853 aa
94.8 kDa 		No 0
AKAP3-002
ENSP00000442376
ENST00000540967
F5H7P4 [Direct mapping]
A-kinase anchor protein 3
Show all
Predicted intracellular proteins
Show all
GO:0005737 [cytoplasm]
GO:0010738 [regulation of protein kinase A signaling]
GO:0035686 [sperm fibrous sheath]
Show all
 162 aa
18.3 kDa 		No 0
AKAP3-004
ENSP00000439382
ENST00000536414
F5H2S4 [Direct mapping]
A-kinase anchor protein 3
Show all
Predicted intracellular proteins
Show all
GO:0005737 [cytoplasm]
GO:0010738 [regulation of protein kinase A signaling]
GO:0035686 [sperm fibrous sheath]
Show all
 96 aa
10.9 kDa 		No 0
AKAP3-201
ENSP00000228850
ENST00000228850
O75969 [Direct mapping]
A-kinase anchor protein 3
V9HWD4 [Target identity:100%; Query identity:100%]
Epididymis luminal protein 159
Show all
Predicted intracellular proteins
Show all
GO:0001669 [acrosomal vesicle]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006928 [movement of cell or subcellular component]
GO:0007178 [transmembrane receptor protein serine/threonine kinase signaling pathway]
GO:0007338 [single fertilization]
GO:0007340 [acrosome reaction]
GO:0008104 [protein localization]
GO:0010738 [regulation of protein kinase A signaling]
GO:0031514 [motile cilium]
GO:0035686 [sperm fibrous sheath]
GO:0051018 [protein kinase A binding]
GO:0097228 [sperm principal piece]
Show all
 853 aa
94.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.