Expression of DUSP16 in cancer - Summary

CANCER ATLAS

Gene description

Dual specificity phosphatase 16

Protein class

Enzymes, Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Testis cancer

STAINING SUMMARY

HPA020326

GENE INFORMATION
Gene name	DUSP16 (HGNC Symbol)
Synonyms	KIAA1700, MKP-7, MKP7
Description	Dual specificity phosphatase 16 (HGNC Symbol)
Entrez gene summary	This gene encodes a mitogen-activated protein kinase phosphatase that is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. The encoded protein specifically regulates the c-Jun amino-terminal kinase (JNK) and extracellular signal-regulated kinase (ERK) pathways.[provided by RefSeq, May 2010]
Chromosome	12
Cytoband	p13.2
Chromosome location (bp)	12474210 - 12562383
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000111266 (version 83.38)
Entrez gene	80824
UniProt	Q9BY84 (UniProt - Evidence at protein level)
neXtProt	NX_Q9BY84
Antibodypedia	DUSP16 antibodies

PROTEIN BROWSER

DUSP16-001	DUSP16-002	DUSP16-003	DUSP16-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
DUSP16-001 ENSP00000298573 ENST00000298573	Q9BY84 [Direct mapping] Dual specificity protein phosphatase 16 A0A024RAR2 [Target identity:100%; Query identity:100%] Dual specificity phosphatase 16, isoform CRA_a Show all	Enzymes ENZYME proteins Hydrolases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all	GO:0000188 [inactivation of MAPK activity] GO:0004721 [phosphoprotein phosphatase activity] GO:0004725 [protein tyrosine phosphatase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006470 [protein dephosphorylation] GO:0008138 [protein tyrosine/serine/threonine phosphatase activity] GO:0016023 [cytoplasmic membrane-bounded vesicle] GO:0016311 [dephosphorylation] GO:0016791 [phosphatase activity] GO:0017017 [MAP kinase tyrosine/serine/threonine phosphatase activity] GO:0035335 [peptidyl-tyrosine dephosphorylation] GO:0043409 [negative regulation of MAPK cascade] GO:0045204 [MAPK export from nucleus] GO:0045209 [MAPK phosphatase export from nucleus, leptomycin B sensitive] Show all	665 aa 73.1 kDa	No	0
DUSP16-002 ENSP00000441250 ENST00000541207		Predicted intracellular proteins Show all		6 aa 0.7 kDa	No	0
DUSP16-003 ENSP00000443039 ENST00000539940	F5H5X4 [Direct mapping] Dual-specificity protein phosphatase 16 Show all	Predicted intracellular proteins Show all	GO:0006470 [protein dephosphorylation] GO:0008138 [protein tyrosine/serine/threonine phosphatase activity] Show all	25 aa 2.8 kDa	No	0
DUSP16-201 ENSP00000228862 ENST00000228862	Q9BY84 [Direct mapping] Dual specificity protein phosphatase 16 Show all	Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Show all	GO:0000188 [inactivation of MAPK activity] GO:0004721 [phosphoprotein phosphatase activity] GO:0004725 [protein tyrosine phosphatase activity] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0006470 [protein dephosphorylation] GO:0008138 [protein tyrosine/serine/threonine phosphatase activity] GO:0016023 [cytoplasmic membrane-bounded vesicle] GO:0016311 [dephosphorylation] GO:0017017 [MAP kinase tyrosine/serine/threonine phosphatase activity] GO:0035335 [peptidyl-tyrosine dephosphorylation] GO:0045204 [MAPK export from nucleus] GO:0045209 [MAPK phosphatase export from nucleus, leptomycin B sensitive] Show all	143 aa 16.1 kDa	No	0