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Weak to moderate cytoplasmic immunoreactivity was observed in most malignant cells. Additional membranous positivity was displayed by colorectal and endometrial cancers. A few cases of colorectal, breast, urothelial,
gastric and occasional pancreatic cancers were strongly stained.
GENE INFORMATION
Gene name
CREBL2
Synonyms
Description
CAMP responsive element binding protein-like 2 (HGNC Symbol)
Entrez gene summary
cAMP response element (CRE)-binding protein-like-2 (CREBL2) was identified in a search to find genes in a commonly deleted region on chromosome 12p13 flanked by ETV6 and CDKN1B genes, frequently associated with hematopoietic malignancies, as well as breast, non-small-cell lung and ovarian cancers. CREBL2 shares a 41% identity with CRE-binding protein (CREB) over a 48-base long region which encodes the bZip domain of CREB. The bZip domain consists of about 30 amino acids rich in basic residues involved in DNA binding, followed by a leucine zipper motif involved in protein dimerization. This suggests that CREBL2 encodes a protein with DNA binding capabilities. The occurance of CREBL2 deletion in malignancy suggests that CREBL2 may act as a tumor suppressor gene. [provided by RefSeq, Jul 2008]
