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A majority of colorectal, breast and liver cancers showed moderate cytoplasmic staining. Gliomas displayed strong cytoplasmic positivity. Remaining cancer tissues were weakly stained or negative.
GENE INFORMATION
Gene name
CDK2AP1 (HGNC Symbol)
Synonyms
doc-1, DOC1, DORC1, p12DOC-1, ST19
Description
Cyclin-dependent kinase 2 associated protein 1 (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene is a cyclin-dependent kinase 2 (CDK2) -associated protein which is thought to negatively regulate CDK2 activity by sequestering monomeric CDK2, and targeting CDK2 for proteolysis. This protein was found to also interact with DNA polymerase alpha/primase and mediate the phosphorylation of the large p180 subunit, which suggests a regulatory role in DNA replication during the S-phase of the cell cycle. This protein also forms a core subunit of the nucleosome remodeling and histone deacetylation (NURD) complex that epigenetically regulates embryonic stem cell differentiation. This gene thus plays a role in both cell-cycle and epigenetic regulation. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2012]