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MGP

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GENERAL INFORMATION

Gene name

 MGP

Gene description

 Matrix Gla protein

Protein class

 Disease related genes
Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

 Intracellular,Secreted

Number of transcripts

 3
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

RNA cell category

 Cell line enriched (AN3-CA)

Protein evidence

 Evidence at protein level

Main location

 Not available

DATA RELIABILITY

Reliability score

 Pending cell analysis.

ASSAYS
RNA expression

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enriched (AN3-CA)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

GENE INFORMATION

Gene name

 MGP

Synonyms

Description

 Matrix Gla protein (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is secreted and likely acts as an inhibitor of bone formation. The encoded protein is found in the organic matrix of bone and cartilage. Defects in this gene are a cause of Keutel syndrome (KS). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]

Chromosome

 12

Cytoband

 p12.3

Chromosome location (bp)

 14881181 - 14885926

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000111341 (version 83.38)

Entrez gene

 4256

UniProt

 P08493 (UniProt - Evidence at protein level)

neXtProt

 NX_P08493

Antibodypedia

 MGP antibodies

PROTEIN BROWSER
MGP-001
MGP-003
MGP-004

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MGP-001
ENSP00000445907
ENST00000539261
P08493 [Direct mapping]
Matrix Gla protein
A0A024RAX0 [Target identity:100%; Query identity:100%]
Matrix Gla protein
Show all
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001502 [cartilage condensation]
GO:0001503 [ossification]
GO:0005201 [extracellular matrix structural constituent]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005578 [proteinaceous extracellular matrix]
GO:0008147 [structural constituent of bone]
GO:0030154 [cell differentiation]
GO:0030500 [regulation of bone mineralization]
GO:0031012 [extracellular matrix]
GO:0070062 [extracellular exosome]
Show all
 103 aa
12.4 kDa 		Yes 0
MGP-003
ENSP00000445436
ENST00000545199
H0YGZ6 [Direct mapping]
Matrix Gla protein
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 74 aa
7.9 kDa 		No 0
MGP-004
ENSP00000228938
ENST00000228938
P08493 [Direct mapping]
Matrix Gla protein
Show all
   MEMSAT3 predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001502 [cartilage condensation]
GO:0001503 [ossification]
GO:0005201 [extracellular matrix structural constituent]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005578 [proteinaceous extracellular matrix]
GO:0008147 [structural constituent of bone]
GO:0030154 [cell differentiation]
GO:0030500 [regulation of bone mineralization]
GO:0031012 [extracellular matrix]
GO:0070062 [extracellular exosome]
Show all
 128 aa
15.3 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.