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ARHGDIB

CANCER ATLAS

Gene description

 Rho GDP dissociation inhibitor (GDI) beta

Protein class

 Plasma proteins, Predicted intracellular proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY
HPA051235
CAB018584

GENE INFORMATION

Gene name

 ARHGDIB (HGNC Symbol)

Synonyms

 GDIA2, GDID4, Ly-GDI, RAP1GN1, RhoGDI2

Description

 Rho GDP dissociation inhibitor (GDI) beta (HGNC Symbol)

Entrez gene summary

 Members of the Rho (or ARH) protein family (see MIM 165390) and other Ras-related small GTP-binding proteins (see MIM 179520) are involved in diverse cellular events, including cell signaling, proliferation, cytoskeletal organization, and secretion. The GTP-binding proteins are active only in the GTP-bound state. At least 3 classes of proteins tightly regulate cycling between the GTP-bound and GDP-bound states: GTPase-activating proteins (GAPs), guanine nucleotide-releasing factors (GRFs), and GDP-dissociation inhibitors (GDIs). The GDIs, including ARHGDIB, decrease the rate of GDP dissociation from Ras-like GTPases (summary by Scherle et al., 1993 [PubMed 8356058]).[supplied by OMIM, Dec 2010]

Chromosome

 12

Cytoband

 p12.3

Chromosome location (bp)

 14942017 - 14961728

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000111348 (version 83.38)

Entrez gene

 397

UniProt

 P52566 (UniProt - Evidence at protein level)

neXtProt

 NX_P52566

Antibodypedia

 ARHGDIB antibodies

PROTEIN BROWSER
ARHGDIB-001
ARHGDIB-002
ARHGDIB-003
ARHGDIB-004
ARHGDIB-005
ARHGDIB-006
ARHGDIB-008

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ARHGDIB-001
ENSP00000228945
ENST00000228945
P52566 [Direct mapping]
Rho GDP-dissociation inhibitor 2
A0A024RAS5 [Target identity:100%; Query identity:100%]
Rho GDP dissociation inhibitor (GDI) beta, isoform CRA_a
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003924 [GTPase activity]
GO:0005094 [Rho GDP-dissociation inhibitor activity]
GO:0005096 [GTPase activator activity]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0006928 [movement of cell or subcellular component]
GO:0006955 [immune response]
GO:0007162 [negative regulation of cell adhesion]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007266 [Rho protein signal transduction]
GO:0007275 [multicellular organismal development]
GO:0016020 [membrane]
GO:0016023 [cytoplasmic membrane-bounded vesicle]
GO:0030036 [actin cytoskeleton organization]
GO:0043547 [positive regulation of GTPase activity]
GO:0050790 [regulation of catalytic activity]
GO:0051056 [regulation of small GTPase mediated signal transduction]
GO:0070062 [extracellular exosome]
GO:0071461 [cellular response to redox state]
GO:1901164 [negative regulation of trophoblast cell migration]
Show all
 201 aa
23 kDa 		No 0
ARHGDIB-002
ENSP00000440560
ENST00000541546
P52566 [Direct mapping]
Rho GDP-dissociation inhibitor 2
A0A024RAS5 [Target identity:100%; Query identity:100%]
Rho GDP dissociation inhibitor (GDI) beta, isoform CRA_a
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003924 [GTPase activity]
GO:0005094 [Rho GDP-dissociation inhibitor activity]
GO:0005096 [GTPase activator activity]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0006928 [movement of cell or subcellular component]
GO:0006955 [immune response]
GO:0007162 [negative regulation of cell adhesion]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007266 [Rho protein signal transduction]
GO:0007275 [multicellular organismal development]
GO:0016023 [cytoplasmic membrane-bounded vesicle]
GO:0030036 [actin cytoskeleton organization]
GO:0043547 [positive regulation of GTPase activity]
GO:0050790 [regulation of catalytic activity]
GO:0051056 [regulation of small GTPase mediated signal transduction]
GO:0070062 [extracellular exosome]
GO:1901164 [negative regulation of trophoblast cell migration]
Show all
 201 aa
23 kDa 		No 0
ARHGDIB-003
ENSP00000445450
ENST00000542276
F5H2R5 [Direct mapping]
Rho GDP-dissociation inhibitor 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005094 [Rho GDP-dissociation inhibitor activity]
GO:0005737 [cytoplasm]
GO:0050790 [regulation of catalytic activity]
Show all
 88 aa
9.8 kDa 		No 0
ARHGDIB-004
ENSP00000437454
ENST00000541380
F5H6Q0 [Direct mapping]
Rho GDP-dissociation inhibitor 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005094 [Rho GDP-dissociation inhibitor activity]
GO:0005737 [cytoplasm]
GO:0050790 [regulation of catalytic activity]
Show all
 112 aa
12.5 kDa 		No 0
ARHGDIB-005
ENSP00000445263
ENST00000545895
F5H3P3 [Direct mapping]
Rho GDP-dissociation inhibitor 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005094 [Rho GDP-dissociation inhibitor activity]
GO:0005737 [cytoplasm]
GO:0050790 [regulation of catalytic activity]
Show all
 159 aa
17.9 kDa 		No 0
ARHGDIB-006
ENSP00000444860
ENST00000541644
P52566 [Direct mapping]
Rho GDP-dissociation inhibitor 2
A0A024RAS5 [Target identity:100%; Query identity:100%]
Rho GDP dissociation inhibitor (GDI) beta, isoform CRA_a
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003924 [GTPase activity]
GO:0005094 [Rho GDP-dissociation inhibitor activity]
GO:0005096 [GTPase activator activity]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0006928 [movement of cell or subcellular component]
GO:0006955 [immune response]
GO:0007162 [negative regulation of cell adhesion]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007266 [Rho protein signal transduction]
GO:0007275 [multicellular organismal development]
GO:0016023 [cytoplasmic membrane-bounded vesicle]
GO:0030036 [actin cytoskeleton organization]
GO:0043547 [positive regulation of GTPase activity]
GO:0050790 [regulation of catalytic activity]
GO:0051056 [regulation of small GTPase mediated signal transduction]
GO:0070062 [extracellular exosome]
GO:1901164 [negative regulation of trophoblast cell migration]
Show all
 201 aa
23 kDa 		No 0
ARHGDIB-008
ENSP00000445185
ENST00000536592
H0YGX7 [Direct mapping]
Rho GDP-dissociation inhibitor 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005094 [Rho GDP-dissociation inhibitor activity]
GO:0005737 [cytoplasm]
GO:0050790 [regulation of catalytic activity]
Show all
 195 aa
22.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.