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GTF2H3

GENERAL INFORMATION

Gene name

 GTF2H3

Gene description

 General transcription factor IIH, polypeptide 3, 34kDa

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 8
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic, membranous and nuclear expression in several tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Uncertain based on 2 antibodies.
HPA004844 , HPA053562
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Esophagus

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 GTF2H3 (HGNC Symbol)

Synonyms

 BTF2, P34, TFIIH

Description

 General transcription factor IIH, polypeptide 3, 34kDa (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the TFB4 family. The encoded protein is a subunit of the core-TFIIH basal transcription factor and localizes to the nucleus. The encoded protein is involved in RNA transcription by RNA polymerase II and nucleotide excision repair and associates with the Cdk-activating kinase complex. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 14. [provided by RefSeq, Dec 2012]

Chromosome

 12

Cytoband

 q24.31

Chromosome location (bp)

 123633739 - 123662606

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000111358 (version 83.38)

Entrez gene

 2967

UniProt

 Q13889 (UniProt - Evidence at protein level)

neXtProt

 NX_Q13889

Antibodypedia

 GTF2H3 antibodies

PROTEIN BROWSER
GTF2H3-001
GTF2H3-002
GTF2H3-003
GTF2H3-004
GTF2H3-008
GTF2H3-011
GTF2H3-013
GTF2H3-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
GTF2H3-001
ENSP00000445162
ENST00000543341
Q13889 [Direct mapping]
General transcription factor IIH subunit 3
Show all
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000439 [core TFIIH complex]
GO:0003684 [damaged DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0004672 [protein kinase activity]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005675 [holo TFIIH complex]
GO:0006281 [DNA repair]
GO:0006283 [transcription-coupled nucleotide-excision repair]
GO:0006289 [nucleotide-excision repair]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006360 [transcription from RNA polymerase I promoter]
GO:0006361 [transcription initiation from RNA polymerase I promoter]
GO:0006362 [transcription elongation from RNA polymerase I promoter]
GO:0006363 [termination of RNA polymerase I transcription]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0006368 [transcription elongation from RNA polymerase II promoter]
GO:0006370 [7-methylguanosine mRNA capping]
GO:0006412 [translation]
GO:0008094 [DNA-dependent ATPase activity]
GO:0008135 [translation factor activity, RNA binding]
GO:0008353 [RNA polymerase II carboxy-terminal domain kinase activity]
GO:0010467 [gene expression]
GO:0016032 [viral process]
GO:0033683 [nucleotide-excision repair, DNA incision]
GO:0040029 [regulation of gene expression, epigenetic]
GO:0045814 [negative regulation of gene expression, epigenetic]
GO:0046872 [metal ion binding]
GO:0047485 [protein N-terminus binding]
GO:0050434 [positive regulation of viral transcription]
GO:0070816 [phosphorylation of RNA polymerase II C-terminal domain]
GO:0070911 [global genome nucleotide-excision repair]
Show all
 308 aa
34.4 kDa 		No 0
GTF2H3-002
ENSP00000228955
ENST00000228955
Q13889 [Direct mapping]
General transcription factor IIH subunit 3
Show all
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000439 [core TFIIH complex]
GO:0003684 [damaged DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0004672 [protein kinase activity]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005675 [holo TFIIH complex]
GO:0006281 [DNA repair]
GO:0006283 [transcription-coupled nucleotide-excision repair]
GO:0006289 [nucleotide-excision repair]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006360 [transcription from RNA polymerase I promoter]
GO:0006361 [transcription initiation from RNA polymerase I promoter]
GO:0006362 [transcription elongation from RNA polymerase I promoter]
GO:0006363 [termination of RNA polymerase I transcription]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0006368 [transcription elongation from RNA polymerase II promoter]
GO:0006370 [7-methylguanosine mRNA capping]
GO:0006412 [translation]
GO:0008094 [DNA-dependent ATPase activity]
GO:0008135 [translation factor activity, RNA binding]
GO:0008353 [RNA polymerase II carboxy-terminal domain kinase activity]
GO:0010467 [gene expression]
GO:0016032 [viral process]
GO:0033683 [nucleotide-excision repair, DNA incision]
GO:0040029 [regulation of gene expression, epigenetic]
GO:0045814 [negative regulation of gene expression, epigenetic]
GO:0046872 [metal ion binding]
GO:0047485 [protein N-terminus binding]
GO:0050434 [positive regulation of viral transcription]
GO:0070816 [phosphorylation of RNA polymerase II C-terminal domain]
GO:0070911 [global genome nucleotide-excision repair]
Show all
 267 aa
29.8 kDa 		No 0
GTF2H3-003
ENSP00000446097
ENST00000538845
F5H4K7 [Direct mapping]
General transcription factor IIH subunit 3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000439 [core TFIIH complex]
GO:0006289 [nucleotide-excision repair]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0070816 [phosphorylation of RNA polymerase II C-terminal domain]
Show all
 210 aa
23.6 kDa 		No 0
GTF2H3-004
ENSP00000446429
ENST00000539994
F5GXG6 [Direct mapping]
General transcription factor IIH subunit 3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000439 [core TFIIH complex]
GO:0006289 [nucleotide-excision repair]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0070816 [phosphorylation of RNA polymerase II C-terminal domain]
Show all
 177 aa
19.8 kDa 		No 0
GTF2H3-008
ENSP00000438435
ENST00000543154
H0YFF7 [Direct mapping]
General transcription factor IIH subunit 3
Show all
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000439 [core TFIIH complex]
GO:0005654 [nucleoplasm]
GO:0006289 [nucleotide-excision repair]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0070816 [phosphorylation of RNA polymerase II C-terminal domain]
Show all
 194 aa
21.9 kDa 		No 0
GTF2H3-011
ENSP00000441894
ENST00000536375
F5GWD3 [Direct mapping]
General transcription factor IIH subunit 3
Show all
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000439 [core TFIIH complex]
GO:0005654 [nucleoplasm]
GO:0006289 [nucleotide-excision repair]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0070816 [phosphorylation of RNA polymerase II C-terminal domain]
Show all
 258 aa
28.9 kDa 		No 0
GTF2H3-013
ENSP00000442977
ENST00000538533
F5H6X0 [Direct mapping]
General transcription factor IIH subunit 3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000439 [core TFIIH complex]
GO:0006289 [nucleotide-excision repair]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0070816 [phosphorylation of RNA polymerase II C-terminal domain]
Show all
 148 aa
16.4 kDa 		No 0
GTF2H3-201
ENSP00000481711
ENST00000618160
A0A087WYD5 [Direct mapping]
General transcription factor IIH subunit 3
Show all
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000439 [core TFIIH complex]
GO:0006289 [nucleotide-excision repair]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0070816 [phosphorylation of RNA polymerase II C-terminal domain]
Show all
 162 aa
18.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.