Expression of DDX55 in cancer - Summary

CANCER ATLAS

Gene description

DEAD (Asp-Glu-Ala-Asp) box polypeptide 55

Protein class

Enzymes, Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA044101

GENE INFORMATION
Gene name	DDX55 (HGNC Symbol)
Synonyms	KIAA1595
Description	DEAD (Asp-Glu-Ala-Asp) box polypeptide 55 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the DEAD box protein family. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of only one transcript has been confirmed. [provided by RefSeq, Jul 2008]
Chromosome	12
Cytoband	q24.31
Chromosome location (bp)	123602077 - 123620941
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000111364 (version 83.38)
Entrez gene	57696
UniProt	Q8NHQ9 (UniProt - Evidence at protein level)
neXtProt	NX_Q8NHQ9
Antibodypedia	DDX55 antibodies

PROTEIN BROWSER

DDX55-001	DDX55-004	DDX55-014

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
DDX55-001 ENSP00000238146 ENST00000238146	Q8NHQ9 [Direct mapping] ATP-dependent RNA helicase DDX55 A0A024RBS0 [Target identity:100%; Query identity:100%] DEAD (Asp-Glu-Ala-Asp) box polypeptide 55, isoform CRA_c Show all	Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0004004 [ATP-dependent RNA helicase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0010501 [RNA secondary structure unwinding] GO:0016020 [membrane] GO:0044822 [poly(A) RNA binding] Show all	600 aa 68.5 kDa	No	0
DDX55-004 ENSP00000443114 ENST00000538744	F5H5U2 [Direct mapping] ATP-dependent RNA helicase DDX55 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0003723 [RNA binding] GO:0004004 [ATP-dependent RNA helicase activity] GO:0005524 [ATP binding] GO:0010501 [RNA secondary structure unwinding] Show all	569 aa 65.2 kDa	No	0
DDX55-014 ENSP00000442332 ENST00000421670	Q8NHQ9 [Direct mapping] ATP-dependent RNA helicase DDX55 Show all	Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004004 [ATP-dependent RNA helicase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0010501 [RNA secondary structure unwinding] GO:0016020 [membrane] GO:0044822 [poly(A) RNA binding] Show all	207 aa 24.3 kDa	No	0