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STX2

GENERAL INFORMATION

Gene name

 STX2

Gene description

 Syntaxin 2

Protein class

 Cancer-related genes
Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Estimation of protein expression could not be performed. View primary data.

DATA RELIABILITY

Data reliability
description

 RNA-based expert annotation gave inconclusive results. Pending external verification. Caution, targets protein from more than one gene.

Reliability score

 Uncertain based on 1 antibody.
HPA069176
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
N/A
Hippocampus
N/A
N/A
Caudate
N/A
N/A
Cerebellum
N/A
N/A
Endocrine tissues
N/A
Bone marrow & immune system
N/A
Appendix
N/A
Tonsil
N/A
Spleen
N/A
Muscle tissues
N/A
Lung
N/A
Nasopharynx
N/A
N/A
Bronchus
N/A
N/A
Lung
N/A
Liver & gallbladder
N/A
Liver
N/A
Pancreas
N/A
Pancreas
N/A
Gastrointestinal tract
N/A
Oral mucosa
N/A
N/A
Esophagus
N/A
Stomach
N/A
Duodenum
N/A
Colon
N/A
Rectum
N/A
Kidney & urinary bladder
N/A
Kidney
N/A
Male tissues
N/A
Testis
N/A
Prostate
N/A
Female tissues
N/A
Breast
N/A
Vagina
N/A
N/A
Ovary
N/A
Placenta
N/A
Adipose & soft tissue
N/A
Soft tissue
N/A
N/A
Skin
N/A
Skin
N/A
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
RNA-based expert annotation could not be performed, due to inconclusive results. View immunohistochemistry primary data.

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 STX2 (HGNC Symbol)

Synonyms

 EPIM, EPM, STX2A, STX2B, STX2C

Description

 Syntaxin 2 (HGNC Symbol)

Entrez gene summary

 The product of this gene belongs to the syntaxin/epimorphin family of proteins. The syntaxins are a large protein family implicated in the targeting and fusion of intracellular transport vesicles. The product of this gene regulates epithelial-mesenchymal interactions and epithelial cell morphogenesis and activation. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

Chromosome

 12

Cytoband

 q24.33

Chromosome location (bp)

 130789600 - 130839266

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000111450 (version 83.38)

Entrez gene

 2054

UniProt

 P32856 (UniProt - Evidence at transcript level)

neXtProt

 NX_P32856

Antibodypedia

 STX2 antibodies

PROTEIN BROWSER
STX2-001
STX2-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
STX2-001
ENSP00000261653
ENST00000261653
P32856 [Direct mapping]
Syntaxin-2
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Cancer-related genes
   Mutated cancer genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000149 [SNARE binding]
GO:0005484 [SNAP receptor activity]
GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0005886 [plasma membrane]
GO:0006886 [intracellular protein transport]
GO:0006887 [exocytosis]
GO:0007165 [signal transduction]
GO:0007340 [acrosome reaction]
GO:0007398 [ectoderm development]
GO:0008021 [synaptic vesicle]
GO:0009887 [organ morphogenesis]
GO:0012505 [endomembrane system]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016192 [vesicle-mediated transport]
GO:0016323 [basolateral plasma membrane]
GO:0030027 [lamellipodium]
GO:0030193 [regulation of blood coagulation]
GO:0031201 [SNARE complex]
GO:0031629 [synaptic vesicle fusion to presynaptic membrane]
GO:0033194 [response to hydroperoxide]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0046983 [protein dimerization activity]
GO:0048278 [vesicle docking]
GO:0048306 [calcium-dependent protein binding]
GO:0051259 [protein oligomerization]
GO:0070062 [extracellular exosome]
GO:1903575 [cornified envelope assembly]
Show all
 287 aa
33.3 kDa 		No 1
STX2-002
ENSP00000376178
ENST00000392373
P32856 [Direct mapping]
Syntaxin-2
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Cancer-related genes
   Mutated cancer genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000149 [SNARE binding]
GO:0005484 [SNAP receptor activity]
GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0005886 [plasma membrane]
GO:0005911 [cell-cell junction]
GO:0006886 [intracellular protein transport]
GO:0006887 [exocytosis]
GO:0007165 [signal transduction]
GO:0007340 [acrosome reaction]
GO:0007398 [ectoderm development]
GO:0008021 [synaptic vesicle]
GO:0009887 [organ morphogenesis]
GO:0009986 [cell surface]
GO:0012505 [endomembrane system]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016192 [vesicle-mediated transport]
GO:0016323 [basolateral plasma membrane]
GO:0030027 [lamellipodium]
GO:0030033 [microvillus assembly]
GO:0030133 [transport vesicle]
GO:0030154 [cell differentiation]
GO:0030193 [regulation of blood coagulation]
GO:0030496 [midbody]
GO:0030855 [epithelial cell differentiation]
GO:0031201 [SNARE complex]
GO:0031410 [cytoplasmic vesicle]
GO:0031629 [synaptic vesicle fusion to presynaptic membrane]
GO:0033194 [response to hydroperoxide]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0045121 [membrane raft]
GO:0046983 [protein dimerization activity]
GO:0048278 [vesicle docking]
GO:0048306 [calcium-dependent protein binding]
GO:0048546 [digestive tract morphogenesis]
GO:0051259 [protein oligomerization]
GO:0070062 [extracellular exosome]
GO:1903575 [cornified envelope assembly]
Show all
 288 aa
33.3 kDa 		No 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.