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Most malignancies showed weak cytoplasmic positivity in a few cases while the remaining cells were negative.
GENE INFORMATION
Gene name
IFNG
Synonyms
Description
Interferon, gamma (HGNC Symbol)
Entrez gene summary
This gene encodes a soluble cytokine that is a member of the type II interferon class. The encoded protein is secreted by cells of the both the innate and adaptive immune systems. The active protein is a homodimer that binds to the interferon gamma receptor which triggers a cellular response to viral and microbial inflections. Mutations in this gene are associated with an increased susceptibility to viral, bacterial and parasitic infections and to several autoimmune diseases. [provided by RefSeq, Sep 2015]