Expression of CPSF6 in cancer - Summary

CANCER ATLAS

Gene description

Cleavage and polyadenylation specific factor 6, 68kDa

Protein class

Plasma proteins, Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA039973

GENE INFORMATION
Gene name	CPSF6 (HGNC Symbol)
Synonyms	CFIM, CFIM68, HPBRII-4, HPBRII-7
Description	Cleavage and polyadenylation specific factor 6, 68kDa (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is one subunit of a cleavage factor required for 3' RNA cleavage and polyadenylation processing. The interaction of the protein with the RNA is one of the earliest steps in the assembly of the 3' end processing complex and facilitates the recruitment of other processing factors. The cleavage factor complex is composed of four polypeptides. This gene encodes the 68kD subunit. It has a domain organization reminiscent of spliceosomal proteins. [provided by RefSeq, Jul 2008]
Chromosome	12
Cytoband	q15
Chromosome location (bp)	69239537 - 69274358
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000111605 (version 83.38)
Entrez gene	11052
UniProt	Q16630 (UniProt - Evidence at protein level)
neXtProt	NX_Q16630
Antibodypedia	CPSF6 antibodies

PROTEIN BROWSER

CPSF6-001	CPSF6-003	CPSF6-004	CPSF6-006

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CPSF6-001 ENSP00000391774 ENST00000435070	Q16630 [Direct mapping] Cleavage and polyadenylation specificity factor subunit 6 Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0003676 [nucleic acid binding] GO:0003723 [RNA binding] GO:0003729 [mRNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005849 [mRNA cleavage factor complex] GO:0006378 [mRNA polyadenylation] GO:0006397 [mRNA processing] GO:0016020 [membrane] GO:0030529 [ribonucleoprotein complex] GO:0042382 [paraspeckles] GO:0044822 [poly(A) RNA binding] GO:0051262 [protein tetramerization] Show all	551 aa 59.2 kDa	No	0
CPSF6-003 ENSP00000391437 ENST00000456847	F8WJN3 [Direct mapping] Cleavage and polyadenylation-specificity factor subunit 6 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0003676 [nucleic acid binding] GO:0005654 [nucleoplasm] Show all	478 aa 52.3 kDa	No	0
CPSF6-004 ENSP00000266679 ENST00000266679	Q16630 [Direct mapping] Cleavage and polyadenylation specificity factor subunit 6 Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0003676 [nucleic acid binding] GO:0003723 [RNA binding] GO:0003729 [mRNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005849 [mRNA cleavage factor complex] GO:0006378 [mRNA polyadenylation] GO:0006397 [mRNA processing] GO:0016020 [membrane] GO:0030529 [ribonucleoprotein complex] GO:0042382 [paraspeckles] GO:0044822 [poly(A) RNA binding] GO:0051262 [protein tetramerization] Show all	588 aa 63.5 kDa	No	0
CPSF6-006 ENSP00000450206 ENST00000551516	F8VNP8 [Direct mapping] Cleavage and polyadenylation-specificity factor subunit 6 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		56 aa 6.2 kDa	No	0