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GAPDH

CANCER ATLAS

Gene description

 Glyceraldehyde-3-phosphate dehydrogenase

Protein class

 Enzymes, Plasma proteins, Predicted intracellular proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA040067
CAB005197
CAB016392

GENE INFORMATION

Gene name

 GAPDH (HGNC Symbol)

Synonyms

 GAPD

Description

 Glyceraldehyde-3-phosphate dehydrogenase (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the glyceraldehyde-3-phosphate dehydrogenase protein family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. The product of this gene catalyzes an important energy-yielding step in carbohydrate metabolism, the reversible oxidative phosphorylation of glyceraldehyde-3-phosphate in the presence of inorganic phosphate and nicotinamide adenine dinucleotide (NAD). The encoded protein has additionally been identified to have uracil DNA glycosylase activity in the nucleus. Also, this protein contains a peptide that has antimicrobial activity against E. coli, P. aeruginosa, and C. albicans. Studies of a similar protein in mouse have assigned a variety of additional functions including nitrosylation of nuclear proteins, the regulation of mRNA stability, and acting as a transferrin receptor on the cell surface of macrophage. Many pseudogenes similar to this locus are present in the human genome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014]

Chromosome

 12

Cytoband

 p13.31

Chromosome location (bp)

 6533927 - 6538374

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000111640 (version 83.38)

Entrez gene

 2597

UniProt

 P04406 (UniProt - Evidence at protein level)

neXtProt

 NX_P04406

Antibodypedia

 GAPDH antibodies

PROTEIN BROWSER
GAPDH-001
GAPDH-002
GAPDH-003
GAPDH-004
GAPDH-008
GAPDH-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
GAPDH-001
ENSP00000229239
ENST00000229239
P04406 [Direct mapping]
Glyceraldehyde-3-phosphate dehydrogenase
V9HVZ4 [Target identity:100%; Query identity:100%]
Glyceraldehyde-3-phosphate dehydrogenase
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000226 [microtubule cytoskeleton organization]
GO:0004365 [glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005811 [lipid particle]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005975 [carbohydrate metabolic process]
GO:0006006 [glucose metabolic process]
GO:0006094 [gluconeogenesis]
GO:0008017 [microtubule binding]
GO:0015630 [microtubule cytoskeleton]
GO:0016020 [membrane]
GO:0016620 [oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor]
GO:0017148 [negative regulation of translation]
GO:0030529 [ribonucleoprotein complex]
GO:0031965 [nuclear membrane]
GO:0031982 [vesicle]
GO:0035605 [peptidyl-cysteine S-nitrosylase activity]
GO:0035606 [peptidyl-cysteine S-trans-nitrosylation]
GO:0042802 [identical protein binding]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0044281 [small molecule metabolic process]
GO:0048471 [perinuclear region of cytoplasm]
GO:0050661 [NADP binding]
GO:0050821 [protein stabilization]
GO:0051287 [NAD binding]
GO:0051402 [neuron apoptotic process]
GO:0055114 [oxidation-reduction process]
GO:0061621 [canonical glycolysis]
GO:0070062 [extracellular exosome]
GO:0071346 [cellular response to interferon-gamma]
GO:0097452 [GAIT complex]
Show all
 335 aa
36.1 kDa 		No 0
GAPDH-002
ENSP00000380070
ENST00000396861
P04406 [Direct mapping]
Glyceraldehyde-3-phosphate dehydrogenase
V9HVZ4 [Target identity:100%; Query identity:100%]
Glyceraldehyde-3-phosphate dehydrogenase
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000226 [microtubule cytoskeleton organization]
GO:0004365 [glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005811 [lipid particle]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005975 [carbohydrate metabolic process]
GO:0006006 [glucose metabolic process]
GO:0006094 [gluconeogenesis]
GO:0008017 [microtubule binding]
GO:0015630 [microtubule cytoskeleton]
GO:0016020 [membrane]
GO:0016620 [oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor]
GO:0017148 [negative regulation of translation]
GO:0030529 [ribonucleoprotein complex]
GO:0031965 [nuclear membrane]
GO:0031982 [vesicle]
GO:0035605 [peptidyl-cysteine S-nitrosylase activity]
GO:0035606 [peptidyl-cysteine S-trans-nitrosylation]
GO:0042802 [identical protein binding]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0044281 [small molecule metabolic process]
GO:0048471 [perinuclear region of cytoplasm]
GO:0050661 [NADP binding]
GO:0050821 [protein stabilization]
GO:0051287 [NAD binding]
GO:0051402 [neuron apoptotic process]
GO:0055114 [oxidation-reduction process]
GO:0061621 [canonical glycolysis]
GO:0070062 [extracellular exosome]
GO:0071346 [cellular response to interferon-gamma]
GO:0097452 [GAIT complex]
Show all
 335 aa
36.1 kDa 		No 0
GAPDH-003
ENSP00000380068
ENST00000396859
P04406 [Direct mapping]
Glyceraldehyde-3-phosphate dehydrogenase
V9HVZ4 [Target identity:100%; Query identity:100%]
Glyceraldehyde-3-phosphate dehydrogenase
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000226 [microtubule cytoskeleton organization]
GO:0004365 [glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005811 [lipid particle]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005975 [carbohydrate metabolic process]
GO:0006006 [glucose metabolic process]
GO:0006094 [gluconeogenesis]
GO:0008017 [microtubule binding]
GO:0015630 [microtubule cytoskeleton]
GO:0016020 [membrane]
GO:0016620 [oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor]
GO:0017148 [negative regulation of translation]
GO:0030529 [ribonucleoprotein complex]
GO:0031965 [nuclear membrane]
GO:0031982 [vesicle]
GO:0035605 [peptidyl-cysteine S-nitrosylase activity]
GO:0035606 [peptidyl-cysteine S-trans-nitrosylation]
GO:0042802 [identical protein binding]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0044281 [small molecule metabolic process]
GO:0048471 [perinuclear region of cytoplasm]
GO:0050661 [NADP binding]
GO:0050821 [protein stabilization]
GO:0051287 [NAD binding]
GO:0051402 [neuron apoptotic process]
GO:0055114 [oxidation-reduction process]
GO:0061621 [canonical glycolysis]
GO:0070062 [extracellular exosome]
GO:0071346 [cellular response to interferon-gamma]
GO:0097452 [GAIT complex]
Show all
 335 aa
36.1 kDa 		No 0
GAPDH-004
ENSP00000380065
ENST00000396856
E7EUT5 [Direct mapping]
Glyceraldehyde-3-phosphate dehydrogenase
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004365 [glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0016620 [oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor]
GO:0031965 [nuclear membrane]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0055114 [oxidation-reduction process]
Show all
 260 aa
27.9 kDa 		No 0
GAPDH-008
ENSP00000380067
ENST00000396858
P04406 [Direct mapping]
Glyceraldehyde-3-phosphate dehydrogenase
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000226 [microtubule cytoskeleton organization]
GO:0004365 [glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005811 [lipid particle]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005975 [carbohydrate metabolic process]
GO:0006006 [glucose metabolic process]
GO:0006094 [gluconeogenesis]
GO:0008017 [microtubule binding]
GO:0015630 [microtubule cytoskeleton]
GO:0016020 [membrane]
GO:0016620 [oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor]
GO:0017148 [negative regulation of translation]
GO:0030529 [ribonucleoprotein complex]
GO:0031965 [nuclear membrane]
GO:0031982 [vesicle]
GO:0035605 [peptidyl-cysteine S-nitrosylase activity]
GO:0035606 [peptidyl-cysteine S-trans-nitrosylation]
GO:0042802 [identical protein binding]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0044281 [small molecule metabolic process]
GO:0048471 [perinuclear region of cytoplasm]
GO:0050661 [NADP binding]
GO:0050821 [protein stabilization]
GO:0051287 [NAD binding]
GO:0051402 [neuron apoptotic process]
GO:0055114 [oxidation-reduction process]
GO:0061621 [canonical glycolysis]
GO:0070062 [extracellular exosome]
GO:0071346 [cellular response to interferon-gamma]
GO:0097452 [GAIT complex]
Show all
 293 aa
31.5 kDa 		No 0
GAPDH-201
ENSP00000478864
ENST00000619601
P04406 [Direct mapping]
Glyceraldehyde-3-phosphate dehydrogenase
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000226 [microtubule cytoskeleton organization]
GO:0004365 [glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005811 [lipid particle]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005975 [carbohydrate metabolic process]
GO:0006006 [glucose metabolic process]
GO:0006094 [gluconeogenesis]
GO:0008017 [microtubule binding]
GO:0015630 [microtubule cytoskeleton]
GO:0016020 [membrane]
GO:0016620 [oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor]
GO:0017148 [negative regulation of translation]
GO:0030529 [ribonucleoprotein complex]
GO:0031965 [nuclear membrane]
GO:0031982 [vesicle]
GO:0035605 [peptidyl-cysteine S-nitrosylase activity]
GO:0035606 [peptidyl-cysteine S-trans-nitrosylation]
GO:0042802 [identical protein binding]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0044281 [small molecule metabolic process]
GO:0048471 [perinuclear region of cytoplasm]
GO:0050661 [NADP binding]
GO:0050821 [protein stabilization]
GO:0051287 [NAD binding]
GO:0051402 [neuron apoptotic process]
GO:0055114 [oxidation-reduction process]
GO:0061621 [canonical glycolysis]
GO:0070062 [extracellular exosome]
GO:0071346 [cellular response to interferon-gamma]
GO:0097452 [GAIT complex]
Show all
 293 aa
31.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.