Cell atlas - ACRBP - The Human Protein Atlas

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ACRBP

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TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nucleoplasm
	Vesicles

Human cell
	Nucleoplasm
	Vesicles

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GENERAL INFORMATION
Gene name	ACRBP
Gene description	Acrosin binding protein
Protein class	Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the nucleoplasm & vesicles.
RNA cell category	Cell line enhanced (U-266/70, U-266/84, HMC-1)
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (approved), Vesicles (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA039082
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (U-266/70, U-266/84, HMC-1) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the nucleoplasm & vesicles.

Main location

Nucleoplasm (approved), Vesicles (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA039082	A-431	Nucleoplasm
	HPA039082	A-431	Vesicles
	HPA039082	U-2 OS	Nucleoplasm
	HPA039082	U-2 OS	Vesicles
	HPA039082	U-251 MG	Nucleoplasm
	HPA039082	U-251 MG	Vesicles

GENE INFORMATION
Gene name	ACRBP (HGNC Symbol)
Synonyms	CT23, OY-TES-1, SP32
Description	Acrosin binding protein (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is similar to proacrosin binding protein sp32 precursor found in mouse, guinea pig, and pig. This protein is located in the sperm acrosome and is thought to function as a binding protein to proacrosin for packaging and condensation of the acrosin zymogen in the acrosomal matrix. This protein is a member of the cancer/testis family of antigens and it is found to be immunogenic. In normal tissues, this mRNA is expressed only in testis, whereas it is detected in a range of different tumor types such as bladder, breast, lung, liver, and colon. [provided by RefSeq, Jul 2008]
Chromosome	12
Cytoband	p13.31
Chromosome location (bp)	6638075 - 6647460
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000111644 (version 83.38)
Entrez gene	84519
UniProt	Q8NEB7 (UniProt - Evidence at transcript level)
neXtProt	NX_Q8NEB7
Antibodypedia	ACRBP antibodies

PROTEIN BROWSER

ACRBP-001	ACRBP-002	ACRBP-008	ACRBP-009

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ACRBP-001 ENSP00000229243 ENST00000229243	Q8NEB7 [Direct mapping] Acrosin-binding protein Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Show all	GO:0001669 [acrosomal vesicle] GO:0003674 [molecular_function] GO:0005576 [extracellular region] GO:0005634 [nucleus] GO:0008150 [biological_process] Show all	543 aa 61.4 kDa	Yes	0
ACRBP-002 ENSP00000402725 ENST00000414226	E7EP66 [Direct mapping] Acrosin-binding protein Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all		510 aa 57.6 kDa	Yes	0
ACRBP-008 ENSP00000438656 ENST00000546114	F5H2C2 [Direct mapping] Acrosin-binding protein Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all		174 aa 19.4 kDa	Yes	0
ACRBP-009 ENSP00000443153 ENST00000536350	F5H5S8 [Direct mapping] Acrosin-binding protein Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all		319 aa 36.2 kDa	Yes	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.