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ENO2

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GENERAL INFORMATION

Gene name

 ENO2

Gene description

 Enolase 2 (gamma, neuronal)

Protein class

 Cancer-related genes
Candidate cardiovascular disease genes
Enzymes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 7
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to the plasma membrane & cytosol. In addition localized to the nucleus. Caution: Based on antibodies targeting proteins from multiple genes.

RNA cell category

 Cell line enhanced (U-87 MG)

Protein evidence

 Evidence at protein level

Main location

 Localized to the Plasma membrane (approved), Cytosol (approved)

Additional location

 In addition localized to the Nucleus (approved)

Single-cell variation

 Single-cell variation in protein expression observed.

DATA RELIABILITY

Reliability score

 Approved based on 1 antibody.
HPA068284
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (U-87 MG)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Mainly localized to the plasma membrane & cytosol. In addition localized to the nucleus. Caution: Based on antibodies targeting proteins from multiple genes.

Main location

 Plasma membrane (approved), Cytosol (approved)

Additional location

 Nucleus (approved)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA068284 HeLa Nucleus
Plasma membrane
Cytosol
HPA068284 U-2 OS Nucleus Intensity
Plasma membrane
Cytosol Intensity

GENE INFORMATION

Gene name

 ENO2

Synonyms

Description

 Enolase 2 (gamma, neuronal) (HGNC Symbol)

Entrez gene summary

 This gene encodes one of the three enolase isoenzymes found in mammals. This isoenzyme, a homodimer, is found in mature neurons and cells of neuronal origin. A switch from alpha enolase to gamma enolase occurs in neural tissue during development in rats and primates. [provided by RefSeq, Jul 2008]

Chromosome

 12

Cytoband

 p13.31

Chromosome location (bp)

 6913745 - 6923698

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000111674 (version 83.38)

Entrez gene

 2026

UniProt

 P09104 (UniProt - Evidence at protein level)

neXtProt

 NX_P09104

Antibodypedia

 ENO2 antibodies

PROTEIN BROWSER
ENO2-001
ENO2-002
ENO2-003
ENO2-004
ENO2-010
ENO2-013
ENO2-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ENO2-001
ENSP00000438873
ENST00000541477
P09104 [Direct mapping]
Gamma-enolase
Q6FHV6 [Target identity:100%; Query identity:100%]
ENO2 protein; Enolase 2 (Gamma, neuronal), isoform CRA_a; Epididymis secretory protein Li 279; cDNA FLJ42665 fis, clone BRAMY2019989, highly similar to Gamma-enolase (EC 4.2.1.11); cDNA, FLJ92734, Homo sapiens enolase 2, (gamma, neuronal) (ENO2), mRNA
Show all
Enzymes
   ENZYME proteins
   Lyases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Candidate cardiovascular disease genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000015 [phosphopyruvate hydratase complex]
GO:0000287 [magnesium ion binding]
GO:0004634 [phosphopyruvate hydratase activity]
GO:0005615 [extracellular space]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005975 [carbohydrate metabolic process]
GO:0006006 [glucose metabolic process]
GO:0006094 [gluconeogenesis]
GO:0006096 [glycolytic process]
GO:0044281 [small molecule metabolic process]
GO:0061621 [canonical glycolysis]
GO:0070062 [extracellular exosome]
Show all
 434 aa
47.3 kDa 		No 0
ENO2-002
ENSP00000437402
ENST00000535366
P09104 [Direct mapping]
Gamma-enolase
Q6FHV6 [Target identity:100%; Query identity:100%]
ENO2 protein; Enolase 2 (Gamma, neuronal), isoform CRA_a; Epididymis secretory protein Li 279; cDNA FLJ42665 fis, clone BRAMY2019989, highly similar to Gamma-enolase (EC 4.2.1.11); cDNA, FLJ92734, Homo sapiens enolase 2, (gamma, neuronal) (ENO2), mRNA
Show all
Enzymes
   ENZYME proteins
   Lyases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Candidate cardiovascular disease genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000015 [phosphopyruvate hydratase complex]
GO:0000287 [magnesium ion binding]
GO:0001917 [photoreceptor inner segment]
GO:0004634 [phosphopyruvate hydratase activity]
GO:0005615 [extracellular space]
GO:0005622 [intracellular]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005975 [carbohydrate metabolic process]
GO:0006006 [glucose metabolic process]
GO:0006094 [gluconeogenesis]
GO:0006096 [glycolytic process]
GO:0043025 [neuronal cell body]
GO:0043204 [perikaryon]
GO:0043209 [myelin sheath]
GO:0044281 [small molecule metabolic process]
GO:0061621 [canonical glycolysis]
GO:0070062 [extracellular exosome]
Show all
 434 aa
47.3 kDa 		No 0
ENO2-003
ENSP00000441490
ENST00000538763
P09104 [Direct mapping]
Gamma-enolase
Show all
Enzymes
   ENZYME proteins
   Lyases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Candidate cardiovascular disease genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000015 [phosphopyruvate hydratase complex]
GO:0000287 [magnesium ion binding]
GO:0004634 [phosphopyruvate hydratase activity]
GO:0005615 [extracellular space]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005975 [carbohydrate metabolic process]
GO:0006006 [glucose metabolic process]
GO:0006094 [gluconeogenesis]
GO:0006096 [glycolytic process]
GO:0044281 [small molecule metabolic process]
GO:0061621 [canonical glycolysis]
GO:0070062 [extracellular exosome]
Show all
 391 aa
42.7 kDa 		No 0
ENO2-004
ENSP00000438062
ENST00000545045
F5H0C8 [Direct mapping]
Enolase
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000015 [phosphopyruvate hydratase complex]
GO:0000287 [magnesium ion binding]
GO:0004634 [phosphopyruvate hydratase activity]
GO:0006096 [glycolytic process]
Show all
 315 aa
34.8 kDa 		No 0
ENO2-010
ENSP00000476112
ENST00000543975
U3KQQ1 [Direct mapping]
Enolase
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000015 [phosphopyruvate hydratase complex]
GO:0000287 [magnesium ion binding]
GO:0004634 [phosphopyruvate hydratase activity]
GO:0006096 [glycolytic process]
Show all
 86 aa
9.4 kDa 		No 0
ENO2-013
ENSP00000445788
ENST00000537688
F5H1C3 [Direct mapping]
Gamma-enolase
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000015 [phosphopyruvate hydratase complex]
GO:0000287 [magnesium ion binding]
GO:0004634 [phosphopyruvate hydratase activity]
GO:0006096 [glycolytic process]
Show all
 103 aa
11.2 kDa 		No 0
ENO2-201
ENSP00000229277
ENST00000229277
P09104 [Direct mapping]
Gamma-enolase
Q6FHV6 [Target identity:100%; Query identity:100%]
ENO2 protein; Enolase 2 (Gamma, neuronal), isoform CRA_a; Epididymis secretory protein Li 279; cDNA FLJ42665 fis, clone BRAMY2019989, highly similar to Gamma-enolase (EC 4.2.1.11); cDNA, FLJ92734, Homo sapiens enolase 2, (gamma, neuronal) (ENO2), mRNA
Show all
Enzymes
   ENZYME proteins
   Lyases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Candidate cardiovascular disease genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000015 [phosphopyruvate hydratase complex]
GO:0000287 [magnesium ion binding]
GO:0004634 [phosphopyruvate hydratase activity]
GO:0005615 [extracellular space]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005975 [carbohydrate metabolic process]
GO:0006006 [glucose metabolic process]
GO:0006094 [gluconeogenesis]
GO:0006096 [glycolytic process]
GO:0044281 [small molecule metabolic process]
GO:0061621 [canonical glycolysis]
GO:0070062 [extracellular exosome]
Show all
 434 aa
47.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.