Cell atlas - C12orf57 - The Human Protein Atlas

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C12orf57

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nuclear speckles

Human cell
	Nucleoplasm

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GENERAL INFORMATION
Gene name	C12orf57
Gene description	Chromosome 12 open reading frame 57
Protein class	Disease related genes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the nuclear speckles.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nuclear speckles (supported)

DATA RELIABILITY
Reliability score	Supported based on 2 antibodies. HPA046182 , HPA066043
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ASSAYS

RNA expression

Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the nuclear speckles.

Main location

Nuclear speckles (supported)


	Toggle channels	Low High G1 S G2 M N/A

Antibody	Cell line	Location
HPA046182	AF22	Nuclear speckles
HPA046182	MCF7	Nuclear speckles
HPA046182	U-2 OS	Nuclear speckles
HPA066043	MCF7	Nuclear speckles
HPA066043	SH-SY5Y	Nuclear speckles
HPA066043	U-2 OS	Nuclear speckles

GENE INFORMATION
Gene name	C12orf57 (HGNC Symbol)
Synonyms	C10, GRCC10
Description	Chromosome 12 open reading frame 57 (HGNC Symbol)
Entrez gene summary	This gene is ubiquitously expressed in human tissues. It is required for development of the human corpus callosum. Mutations in this gene are associated with Temtamy syndrome (TEMTYS). Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2014]
Chromosome	12
Cytoband	p13.31
Chromosome location (bp)	6942978 - 6946003
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000111678 (version 83.38)
Entrez gene	113246
UniProt	Q99622 (UniProt - Evidence at protein level)
neXtProt	NX_Q99622
Antibodypedia	C12orf57 antibodies

PROTEIN BROWSER

C12orf57-001	C12orf57-003	C12orf57-004	C12orf57-005	C12orf57-006

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
C12orf57-001 ENSP00000229281 ENST00000229281	Q99622 [Direct mapping] Protein C10 Show all	Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005737 [cytoplasm] Show all	126 aa 13.2 kDa	No	0
C12orf57-003 ENSP00000440602 ENST00000545581	Q99622 [Direct mapping] Protein C10 Show all	Predicted intracellular proteins Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0005737 [cytoplasm] Show all	126 aa 13.2 kDa	No	0
C12orf57-004 ENSP00000475422 ENST00000544681	U3KQ07 [Direct mapping] Protein C10 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		103 aa 10.5 kDa	No	0
C12orf57-005 ENSP00000475635 ENST00000540506	U3KQ85 [Direct mapping] Protein C10 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		91 aa 9.6 kDa	No	0
C12orf57-006 ENSP00000440937 ENST00000537087	F5GXW5 [Direct mapping] Protein C10 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		97 aa 10 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.