Expression of ST8SIA1 in cancer - Summary

CANCER ATLAS

Gene description

ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1

Protein class

Enzymes, Predicted intracellular proteins, Predicted membrane proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Melanoma

STAINING SUMMARY

HPA026775

GENE INFORMATION
Gene name	ST8SIA1 (HGNC Symbol)
Synonyms	SIAT8, SIAT8A
Description	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1 (HGNC Symbol)
Entrez gene summary	Gangliosides are membrane-bound glycosphingolipids containing sialic acid. Ganglioside GD3 is known to be important for cell adhesion and growth of cultured malignant cells. The protein encoded by this gene is a type II membrane protein that catalyzes the transfer of sialic acid from CMP-sialic acid to GM3 to produce gangliosides GD3 and GT3. The encoded protein may be found in the Golgi apparatus and is a member of glycosyltransferase family 29. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2015]
Chromosome	12
Cytoband	p12.1
Chromosome location (bp)	22063773 - 22437041
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000111728 (version 83.38)
Entrez gene	6489
UniProt	Q92185 (UniProt - Evidence at protein level)
neXtProt	NX_Q92185
Antibodypedia	ST8SIA1 antibodies

PROTEIN BROWSER

ST8SIA1-001	ST8SIA1-002	ST8SIA1-003	ST8SIA1-006	ST8SIA1-011	ST8SIA1-012

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ST8SIA1-001 ENSP00000379353 ENST00000396037	Q92185 [Direct mapping] Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase Show all	Enzymes ENZYME proteins Transferases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Show all	GO:0000139 [Golgi membrane] GO:0003828 [alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity] GO:0005975 [carbohydrate metabolic process] GO:0006486 [protein glycosylation] GO:0006488 [dolichol-linked oligosaccharide biosynthetic process] GO:0006688 [glycosphingolipid biosynthetic process] GO:0008284 [positive regulation of cell proliferation] GO:0008373 [sialyltransferase activity] GO:0016021 [integral component of membrane] GO:0018279 [protein N-linked glycosylation via asparagine] GO:0030173 [integral component of Golgi membrane] GO:0034605 [cellular response to heat] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0097503 [sialylation] Show all	356 aa 40.5 kDa	No	2
ST8SIA1-002 ENSP00000384467 ENST00000404299	F8WCS8 [Direct mapping] Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0016021 [integral component of membrane] Show all	120 aa 13.5 kDa	No	1
ST8SIA1-003 ENSP00000370832 ENST00000381424	Q86X71 [Direct mapping] Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; ST8SIA1 protein Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0016021 [integral component of membrane] Show all	83 aa 9.3 kDa	No	1
ST8SIA1-006 ENSP00000441707 ENST00000540824	H0YG41 [Direct mapping] Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase Show all	Predicted intracellular proteins Show all	GO:0005794 [Golgi apparatus] GO:0006486 [protein glycosylation] GO:0008373 [sialyltransferase activity] GO:0016021 [integral component of membrane] GO:0097503 [sialylation] Show all	191 aa 22 kDa	No	0
ST8SIA1-011 ENSP00000440292 ENST00000541868	H0YFU1 [Direct mapping] Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Phobius predicted secreted proteins Predicted intracellular proteins Show all	GO:0005794 [Golgi apparatus] GO:0006486 [protein glycosylation] GO:0008373 [sialyltransferase activity] GO:0016021 [integral component of membrane] GO:0097503 [sialylation] Show all	172 aa 19.4 kDa	No	0
ST8SIA1-012 ENSP00000444999 ENST00000538256	H0YGV9 [Direct mapping] Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase Show all	Predicted intracellular proteins Show all		24 aa 2.8 kDa	No	0