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CLEC4A

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GENERAL INFORMATION

Gene name

 CLEC4A

Gene description

 C-type lectin domain family 4, member A

Protein class

 Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

 Intracellular,Membrane

Number of transcripts

 5
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

RNA cell category

 Mixed

Protein evidence

 Evidence at protein level

Main location

 Not available

DATA RELIABILITY

Reliability score

 Pending cell analysis.

ASSAYS
RNA expression

RNA EXPRESSION OVERVIEW
RNA cell line category: Mixed
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

GENE INFORMATION

Gene name

 CLEC4A (HGNC Symbol)

Synonyms

 CD367, CLECSF6, DCIR, DDB27

Description

 C-type lectin domain family 4, member A (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. The encoded type 2 transmembrane protein may play a role in inflammatory and immune response. Multiple transcript variants encoding distinct isoforms have been identified for this gene. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region. [provided by RefSeq, Jul 2008]

Chromosome

 12

Cytoband

 p13.31

Chromosome location (bp)

 8123632 - 8138607

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000111729 (version 83.38)

Entrez gene

 50856

UniProt

 Q9UMR7 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9UMR7

Antibodypedia

 CLEC4A antibodies

PROTEIN BROWSER
CLEC4A-001
CLEC4A-002
CLEC4A-003
CLEC4A-004
CLEC4A-005

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CLEC4A-001
ENSP00000229332
ENST00000229332
Q9UMR7 [Direct mapping]
C-type lectin domain family 4 member A
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Show all
GO:0002223 [stimulatory C-type lectin receptor signaling pathway]
GO:0002250 [adaptive immune response]
GO:0004888 [transmembrane signaling receptor activity]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0007155 [cell adhesion]
GO:0007166 [cell surface receptor signaling pathway]
GO:0030246 [carbohydrate binding]
GO:0045087 [innate immune response]
Show all
 237 aa
27.5 kDa 		No 1
CLEC4A-002
ENSP00000247243
ENST00000352620
Q9UMR7 [Direct mapping]
C-type lectin domain family 4 member A
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Show all
GO:0002223 [stimulatory C-type lectin receptor signaling pathway]
GO:0002250 [adaptive immune response]
GO:0004888 [transmembrane signaling receptor activity]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0007155 [cell adhesion]
GO:0007166 [cell surface receptor signaling pathway]
GO:0030246 [carbohydrate binding]
GO:0045087 [innate immune response]
Show all
 204 aa
23.6 kDa 		No 1
CLEC4A-003
ENSP00000443082
ENST00000546339
H0YGF9 [Direct mapping]
C-type lectin domain family 4 member A
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Show all
GO:0016021 [integral component of membrane]
Show all
 84 aa
9.2 kDa 		No 1
CLEC4A-004
ENSP00000344646
ENST00000345999
Q9UMR7 [Direct mapping]
C-type lectin domain family 4 member A
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Show all
GO:0002223 [stimulatory C-type lectin receptor signaling pathway]
GO:0002250 [adaptive immune response]
GO:0004888 [transmembrane signaling receptor activity]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0007155 [cell adhesion]
GO:0007166 [cell surface receptor signaling pathway]
GO:0030246 [carbohydrate binding]
GO:0045087 [innate immune response]
Show all
 165 aa
19.3 kDa 		No 0
CLEC4A-005
ENSP00000353690
ENST00000360500
Q9UMR7 [Direct mapping]
C-type lectin domain family 4 member A
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Show all
GO:0002223 [stimulatory C-type lectin receptor signaling pathway]
GO:0002250 [adaptive immune response]
GO:0004888 [transmembrane signaling receptor activity]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0007155 [cell adhesion]
GO:0007166 [cell surface receptor signaling pathway]
GO:0030246 [carbohydrate binding]
GO:0045087 [innate immune response]
Show all
 198 aa
23.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.