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AICDA

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GENERAL INFORMATION

Gene name

 AICDA

Gene description

 Activation-induced cytidine deaminase

Protein class

 Disease related genes
Enzymes
Potential drug targets
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 5
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

RNA cell category

 Group enriched (Daudi, U-698)

Protein evidence

 Evidence at protein level

Main location

 Not available

DATA RELIABILITY

Reliability score

 Pending cell analysis.

ASSAYS
RNA expression

RNA EXPRESSION OVERVIEW
RNA cell line category: Group enriched (Daudi, U-698)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

GENE INFORMATION

Gene name

 AICDA (HGNC Symbol)

Synonyms

 AID, ARP2, CDA2, HIGM2

Description

 Activation-induced cytidine deaminase (HGNC Symbol)

Entrez gene summary

 This gene encodes a RNA-editing deaminase that is a member of the cytidine deaminase family. The protein is involved in somatic hypermutation, gene conversion, and class-switch recombination of immunoglobulin genes. Defects in this gene are the cause of autosomal recessive hyper-IgM immunodeficiency syndrome type 2 (HIGM2). [provided by RefSeq, Feb 2009]

Chromosome

 12

Cytoband

 p13.31

Chromosome location (bp)

 8602166 - 8612871

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000111732 (version 83.38)

Entrez gene

 57379

UniProt

 Q9GZX7 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9GZX7

Antibodypedia

 AICDA antibodies

PROTEIN BROWSER
AICDA-001
AICDA-002
AICDA-003
AICDA-004
AICDA-005

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
AICDA-001
ENSP00000229335
ENST00000229335
Q9GZX7 [Direct mapping]
Single-stranded DNA cytosine deaminase
Q546Y9 [Target identity:100%; Query identity:100%]
AID; Activation-induced cytidine deaminase; Epididymis secretory protein Li 284
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Disease related genes
Potential drug targets
Show all
GO:0000178 [exosome (RNase complex)]
GO:0003824 [catalytic activity]
GO:0004126 [cytidine deaminase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006397 [mRNA processing]
GO:0008270 [zinc ion binding]
GO:0009972 [cytidine deamination]
GO:0016445 [somatic diversification of immunoglobulins]
GO:0016446 [somatic hypermutation of immunoglobulin genes]
GO:0016787 [hydrolase activity]
GO:0016814 [hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines]
GO:0030183 [B cell differentiation]
GO:0031625 [ubiquitin protein ligase binding]
GO:0045190 [isotype switching]
GO:0071222 [cellular response to lipopolysaccharide]
GO:0080111 [DNA demethylation]
GO:0090310 [negative regulation of methylation-dependent chromatin silencing]
Show all
 198 aa
24 kDa 		No 0
AICDA-002
ENSP00000443060
ENST00000545512
H0YGF6 [Direct mapping]
Single-stranded DNA cytosine deaminase
Show all
Predicted intracellular proteins
Show all
GO:0003824 [catalytic activity]
GO:0008152 [metabolic process]
GO:0008270 [zinc ion binding]
GO:0016787 [hydrolase activity]
GO:0016814 [hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines]
Show all
 197 aa
23.7 kDa 		No 0
AICDA-003
ENSP00000439538
ENST00000544516
H0YFP1 [Direct mapping]
Single-stranded DNA cytosine deaminase
Show all
Predicted intracellular proteins
Show all
GO:0008152 [metabolic process]
GO:0008270 [zinc ion binding]
GO:0016814 [hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines]
Show all
 68 aa
8.2 kDa 		No 0
AICDA-004
ENSP00000439103
ENST00000543081
H0YFL3 [Direct mapping]
Single-stranded DNA cytosine deaminase
Show all
Predicted intracellular proteins
Show all
GO:0003824 [catalytic activity]
GO:0008152 [metabolic process]
GO:0008270 [zinc ion binding]
GO:0016787 [hydrolase activity]
GO:0016814 [hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines]
Show all
 144 aa
17.1 kDa 		No 0
AICDA-005
ENSP00000445691
ENST00000537228
Q9GZX7 [Direct mapping]
Single-stranded DNA cytosine deaminase
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Disease related genes
Potential drug targets
Show all
GO:0000178 [exosome (RNase complex)]
GO:0003824 [catalytic activity]
GO:0004126 [cytidine deaminase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006397 [mRNA processing]
GO:0008270 [zinc ion binding]
GO:0016445 [somatic diversification of immunoglobulins]
GO:0016446 [somatic hypermutation of immunoglobulin genes]
GO:0016787 [hydrolase activity]
GO:0016814 [hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines]
GO:0030183 [B cell differentiation]
GO:0031625 [ubiquitin protein ligase binding]
GO:0080111 [DNA demethylation]
GO:0090310 [negative regulation of methylation-dependent chromatin silencing]
Show all
 188 aa
22.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.