Expression of COX6A1 in cancer - Summary

CANCER ATLAS

Gene description

Cytochrome c oxidase subunit VIa polypeptide 1

Protein class

Disease related genes, Predicted membrane proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Melanoma

STAINING SUMMARY

HPA062394

GENE INFORMATION
Gene name	COX6A1 (HGNC Symbol)
Synonyms	COX6A
Description	Cytochrome c oxidase subunit VIa polypeptide 1 (HGNC Symbol)
Entrez gene summary	Cytochrome c oxidase (COX), the terminal enzyme of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. It is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in the electron transfer and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes polypeptide 1 (liver isoform) of subunit VIa, and polypeptide 1 is found in all non-muscle tissues. Polypeptide 2 (heart/muscle isoform) of subunit VIa is encoded by a different gene, and is present only in striated muscles. These two polypeptides share 66% amino acid sequence identity. It has been reported that there may be several pseudogenes on chromosomes 1, 6, 7q21, 7q31-32 and 12. However, only one pseudogene (COX6A1P) on chromosome 1p31.1 has been documented. [provided by RefSeq, Jul 2008]
Chromosome	12
Cytoband	q24.31
Chromosome location (bp)	120438090 - 120440742
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000111775 (version 83.38)
Entrez gene	1337
UniProt	P12074 (UniProt - Evidence at protein level)
neXtProt	NX_P12074
Antibodypedia	COX6A1 antibodies

PROTEIN BROWSER

COX6A1-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
COX6A1-001 ENSP00000229379 ENST00000229379	P12074 [Direct mapping] Cytochrome c oxidase subunit 6A1, mitochondrial H6SG15 [Target identity:100%; Query identity:100%] Cytochrome c oxidase subunit 6A, mitochondrial Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Protein evidence (Kim et al 2014) Show all	GO:0004129 [cytochrome-c oxidase activity] GO:0005739 [mitochondrion] GO:0005743 [mitochondrial inner membrane] GO:0005751 [mitochondrial respiratory chain complex IV] GO:0006091 [generation of precursor metabolites and energy] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0010467 [gene expression] GO:0022904 [respiratory electron transport chain] GO:0044237 [cellular metabolic process] GO:0044281 [small molecule metabolic process] GO:1902600 [hydrogen ion transmembrane transport] Show all	109 aa 12.2 kDa	No	1