Expression of KLRB1 in cancer - Summary

CANCER ATLAS

Gene description

Killer cell lectin-like receptor subfamily B, member 1

Protein class

CD markers, Predicted membrane proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA039113

GENE INFORMATION
Gene name	KLRB1 (HGNC Symbol)
Synonyms	CD161, CLEC5B, hNKR-P1A, NKR, NKR-P1, NKR-P1A
Description	Killer cell lectin-like receptor subfamily B, member 1 (HGNC Symbol)
Entrez gene summary	Natural killer (NK) cells are lymphocytes that mediate cytotoxicity and secrete cytokines after immune stimulation. Several genes of the C-type lectin superfamily, including the rodent NKRP1 family of glycoproteins, are expressed by NK cells and may be involved in the regulation of NK cell function. The KLRB1 protein contains an extracellular domain with several motifs characteristic of C-type lectins, a transmembrane domain, and a cytoplasmic domain. The KLRB1 protein is classified as a type II membrane protein because it has an external C terminus. [provided by RefSeq, Jul 2008]
Chromosome	12
Cytoband	p13.31
Chromosome location (bp)	9594551 - 9607886
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000111796 (version 83.38)
Entrez gene	3820
UniProt	Q12918 (UniProt - Evidence at protein level)
neXtProt	NX_Q12918
Antibodypedia	KLRB1 antibodies

PROTEIN BROWSER

KLRB1-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
KLRB1-001 ENSP00000229402 ENST00000229402	Q12918 [Direct mapping] Killer cell lectin-like receptor subfamily B member 1 Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0004888 [transmembrane signaling receptor activity] GO:0005886 [plasma membrane] GO:0007166 [cell surface receptor signaling pathway] GO:0016021 [integral component of membrane] GO:0030246 [carbohydrate binding] GO:0050776 [regulation of immune response] Show all	225 aa 25.4 kDa	No	1