Expression of COL12A1 in cancer - Summary

CANCER ATLAS

Gene description

Collagen, type XII, alpha 1

Protein class

Disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA009143

GENE INFORMATION
Gene name	COL12A1 (HGNC Symbol)
Synonyms	COL12A1L
Description	Collagen, type XII, alpha 1 (HGNC Symbol)
Entrez gene summary	This gene encodes the alpha chain of type XII collagen, a member of the FACIT (fibril-associated collagens with interrupted triple helices) collagen family. Type XII collagen is a homotrimer found in association with type I collagen, an association that is thought to modify the interactions between collagen I fibrils and the surrounding matrix. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Chromosome	6
Cytoband
Chromosome location (bp)	75084326 - 75206051
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000111799 (version 83.38)
Entrez gene	1303
UniProt	Q99715 (UniProt - Evidence at protein level)
neXtProt	NX_Q99715
Antibodypedia	COL12A1 antibodies

PROTEIN BROWSER

COL12A1-001	COL12A1-002	COL12A1-003	COL12A1-006	COL12A1-007	COL12A1-008	COL12A1-009	COL12A1-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
COL12A1-001 ENSP00000325146 ENST00000322507	Q99715 [Direct mapping] Collagen alpha-1(XII) chain Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001501 [skeletal system development] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005595 [collagen type XII trimer] GO:0005615 [extracellular space] GO:0005788 [endoplasmic reticulum lumen] GO:0007155 [cell adhesion] GO:0022617 [extracellular matrix disassembly] GO:0030020 [extracellular matrix structural constituent conferring tensile strength] GO:0030198 [extracellular matrix organization] GO:0030199 [collagen fibril organization] GO:0030574 [collagen catabolic process] GO:0031012 [extracellular matrix] GO:0035987 [endodermal cell differentiation] GO:0070062 [extracellular exosome] GO:1903561 [extracellular vesicle] Show all	3063 aa 333.1 kDa	Yes	0
COL12A1-002 ENSP00000305147 ENST00000345356	Q99715 [Direct mapping] Collagen alpha-1(XII) chain Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins Plasma proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001501 [skeletal system development] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005595 [collagen type XII trimer] GO:0005615 [extracellular space] GO:0005788 [endoplasmic reticulum lumen] GO:0007155 [cell adhesion] GO:0022617 [extracellular matrix disassembly] GO:0030020 [extracellular matrix structural constituent conferring tensile strength] GO:0030198 [extracellular matrix organization] GO:0030199 [collagen fibril organization] GO:0030574 [collagen catabolic process] GO:0031012 [extracellular matrix] GO:0035987 [endodermal cell differentiation] GO:0070062 [extracellular exosome] GO:1903561 [extracellular vesicle] Show all	1899 aa 205.5 kDa	Yes	0
COL12A1-003 ENSP00000421216 ENST00000483888	D6RGG3 [Direct mapping] Collagen alpha-1(XII) chain Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	3062 aa 333.2 kDa	Yes	0
COL12A1-006 ENSP00000423423 ENST00000493109	H0Y991 [Direct mapping] Collagen alpha-1(XII) chain Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		207 aa 23.2 kDa	No	0
COL12A1-007 ENSP00000393217 ENST00000419671	H0Y4P7 [Direct mapping] Collagen alpha-1(XII) chain Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	638 aa 70.8 kDa	No	0
COL12A1-008 ENSP00000399812 ENST00000425443	H0Y5N9 [Direct mapping] Collagen alpha-1(XII) chain Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		756 aa 79.8 kDa	No	0
COL12A1-009 ENSP00000412864 ENST00000416123	Q99715 [Direct mapping] Collagen alpha-1(XII) chain Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0001501 [skeletal system development] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005595 [collagen type XII trimer] GO:0005615 [extracellular space] GO:0005788 [endoplasmic reticulum lumen] GO:0007155 [cell adhesion] GO:0022617 [extracellular matrix disassembly] GO:0030020 [extracellular matrix structural constituent conferring tensile strength] GO:0030198 [extracellular matrix organization] GO:0030199 [collagen fibril organization] GO:0030574 [collagen catabolic process] GO:0031012 [extracellular matrix] GO:0035987 [endodermal cell differentiation] GO:0070062 [extracellular exosome] GO:1903561 [extracellular vesicle] Show all	2987 aa 324.6 kDa	Yes	0
COL12A1-201 ENSP00000483232 ENST00000615798	A0A087X0A8 [Direct mapping] Collagen alpha-1(XII) chain Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	1874 aa 203.1 kDa	No	0