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Several colorectal, breast and prostate cancers as well as cases of endometrial, skin, gastric and pancreatic cancers showed moderate cytoplasmic and membranous staining. Remaining malignant cells were weakly stained or negative.
Moderate to strong cytoplasmic positivity often with a granular pattern was observed in prostate cancers along with several endometrial, breast, colorectal and few ovarian cancers. Remaining cancers were generally negative.
GENE INFORMATION
Gene name
RSPH4A (HGNC Symbol)
Synonyms
CILD11, dJ412I7.1, FLJ37974, RSHL3, RSPH6B
Description
Radial spoke head 4 homolog A (Chlamydomonas) (HGNC Symbol)
Entrez gene summary
This gene encodes a protein that appears to be a component the radial spoke head, as determined by homology to similar proteins in the biflagellate alga Chlamydomonas reinhardtii and other ciliates. Radial spokes, which are regularly spaced along cilia, sperm, and flagella axonemes, consist of a thin 'stalk' and a bulbous 'head' that form a signal transduction scaffold between the central pair of microtubules and dynein. Mutations in this gene cause primary ciliary dyskinesia 1, a disease arising from dysmotility of motile cilia and sperm. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2009]
