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Cancer tissues displayed weak to moderate cytoplasmic staining with additional membranous positivity in rare cases. Few cases of liver cancers were strongly positive. Majority of gliomas, lymphomas, melanomas, urothelial, renal and endometrial cancers were negative.
Strong cytoplasmic positivity with a granular pattern was observed in cancer cells.
GENE INFORMATION
Gene name
MAN1A1
Synonyms
Description
Mannosidase, alpha, class 1A, member 1 (HGNC Symbol)
Entrez gene summary
This gene encodes a class I mammalian Golgi 1,2-mannosidase which is a type II transmembrane protein. This protein catalyzes the hydrolysis of three terminal mannose residues from peptide-bound Man(9)-GlcNAc(2) oligosaccharides and belongs to family 47 of glycosyl hydrolases. [provided by RefSeq, Jul 2012]