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OPRM1

GENERAL INFORMATION

Gene name

 OPRM1

Gene description

 Opioid receptor, mu 1

Protein class

 FDA approved drug targets
G-protein coupled receptors
Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 16
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (testis)
GTEx:Group enriched (testis, cerebellum)
FANTOM5:Tissue enhanced (cerebellum, caudate)

Protein evidence

 Evidence at protein level

Protein expression

 Membranous expression in seminiferous tubules.

DATA RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data. Pending external verification.

Reliability score

 Supported based on 1 antibody.
HPA014509
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (testis)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (testis, cerebellum)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (cerebellum, caudate)

GENE INFORMATION

Gene name

 OPRM1 (HGNC Symbol)

Synonyms

 MOR1

Description

 Opioid receptor, mu 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes one of at least three opioid receptors in humans; the mu opioid receptor (MOR). The MOR is the principal target of endogenous opioid peptides and opioid analgesic agents such as beta-endorphin and enkephalins. The MOR also has an important role in dependence to other drugs of abuse, such as nicotine, cocaine, and alcohol via its modulation of the dopamine system. The NM_001008503.2:c.118A>G allele has been associated with opioid and alcohol addiction and variations in pain sensitivity but evidence for it having a causal role is conflicting. Multiple transcript variants encoding different isoforms have been found for this gene. Though the canonical MOR belongs to the superfamily of 7-transmembrane-spanning G-protein-coupled receptors some isoforms of this gene have only 6 transmembrane domains. [provided by RefSeq, Oct 2013]

Chromosome

 6

Cytoband

 q25.2

Chromosome location (bp)

 154010496 - 154246867

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000112038 (version 83.38)

Entrez gene

 4988

UniProt

 P35372 (UniProt - Evidence at protein level)

neXtProt

 NX_P35372

Antibodypedia

 OPRM1 antibodies

PROTEIN BROWSER
«
OPRM1-001
OPRM1-002
OPRM1-003
OPRM1-004
OPRM1-005
OPRM1-006
OPRM1-008
OPRM1-010
OPRM1-012
OPRM1-013
OPRM1-014
OPRM1-016
OPRM1-017
OPRM1-019
OPRM1-020
OPRM1-201
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
OPRM1-001
ENSP00000328264
ENST00000330432
P35372 [Direct mapping]
Mu-type opioid receptor
Show all
G-protein coupled receptors
   GPCRs excl olfactory receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
FDA approved drug targets
   Small molecule drugs
Show all
GO:0001965 [G-protein alpha-subunit binding]
GO:0004930 [G-protein coupled receptor activity]
GO:0004979 [beta-endorphin receptor activity]
GO:0005245 [voltage-gated calcium channel activity]
GO:0005515 [protein binding]
GO:0005783 [endoplasmic reticulum]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007187 [G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger]
GO:0007194 [negative regulation of adenylate cyclase activity]
GO:0007200 [phospholipase C-activating G-protein coupled receptor signaling pathway]
GO:0007204 [positive regulation of cytosolic calcium ion concentration]
GO:0007218 [neuropeptide signaling pathway]
GO:0007268 [synaptic transmission]
GO:0007600 [sensory perception]
GO:0008285 [negative regulation of cell proliferation]
GO:0016021 [integral component of membrane]
GO:0019233 [sensory perception of pain]
GO:0031681 [G-protein beta-subunit binding]
GO:0033554 [cellular response to stress]
GO:0038003 [opioid receptor signaling pathway]
GO:0038047 [morphine receptor activity]
GO:0042923 [neuropeptide binding]
GO:0043005 [neuron projection]
GO:0043950 [positive regulation of cAMP-mediated signaling]
GO:0043951 [negative regulation of cAMP-mediated signaling]
GO:0045019 [negative regulation of nitric oxide biosynthetic process]
GO:0045429 [positive regulation of nitric oxide biosynthetic process]
GO:0048149 [behavioral response to ethanol]
GO:0050769 [positive regulation of neurogenesis]
GO:0051481 [negative regulation of cytosolic calcium ion concentration]
GO:0061358 [negative regulation of Wnt protein secretion]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0070588 [calcium ion transmembrane transport]
GO:0071315 [cellular response to morphine]
GO:2000310 [regulation of N-methyl-D-aspartate selective glutamate receptor activity]
Show all
 400 aa
44.8 kDa 		No 7
OPRM1-002
ENSP00000411903
ENST00000428397
P35372 [Direct mapping]
Mu-type opioid receptor
Show all
G-protein coupled receptors
   GPCRs excl olfactory receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
FDA approved drug targets
   Small molecule drugs
Show all
GO:0001965 [G-protein alpha-subunit binding]
GO:0004930 [G-protein coupled receptor activity]
GO:0004979 [beta-endorphin receptor activity]
GO:0005245 [voltage-gated calcium channel activity]
GO:0005515 [protein binding]
GO:0005783 [endoplasmic reticulum]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007187 [G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger]
GO:0007194 [negative regulation of adenylate cyclase activity]
GO:0007200 [phospholipase C-activating G-protein coupled receptor signaling pathway]
GO:0007204 [positive regulation of cytosolic calcium ion concentration]
GO:0007218 [neuropeptide signaling pathway]
GO:0007268 [synaptic transmission]
GO:0007600 [sensory perception]
GO:0008285 [negative regulation of cell proliferation]
GO:0016021 [integral component of membrane]
GO:0019233 [sensory perception of pain]
GO:0031681 [G-protein beta-subunit binding]
GO:0033554 [cellular response to stress]
GO:0038003 [opioid receptor signaling pathway]
GO:0038047 [morphine receptor activity]
GO:0042923 [neuropeptide binding]
GO:0043005 [neuron projection]
GO:0043950 [positive regulation of cAMP-mediated signaling]
GO:0043951 [negative regulation of cAMP-mediated signaling]
GO:0045019 [negative regulation of nitric oxide biosynthetic process]
GO:0045429 [positive regulation of nitric oxide biosynthetic process]
GO:0048149 [behavioral response to ethanol]
GO:0050769 [positive regulation of neurogenesis]
GO:0051481 [negative regulation of cytosolic calcium ion concentration]
GO:0061358 [negative regulation of Wnt protein secretion]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0070588 [calcium ion transmembrane transport]
GO:0071315 [cellular response to morphine]
GO:2000310 [regulation of N-methyl-D-aspartate selective glutamate receptor activity]
Show all
 392 aa
44 kDa 		No 7
OPRM1-003
ENSP00000394624
ENST00000434900
P35372 [Direct mapping]
Mu-type opioid receptor
Show all
G-protein coupled receptors
   GPCRs excl olfactory receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
FDA approved drug targets
   Small molecule drugs
Show all
GO:0001965 [G-protein alpha-subunit binding]
GO:0002438 [acute inflammatory response to antigenic stimulus]
GO:0004930 [G-protein coupled receptor activity]
GO:0004979 [beta-endorphin receptor activity]
GO:0004985 [opioid receptor activity]
GO:0005245 [voltage-gated calcium channel activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005783 [endoplasmic reticulum]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005925 [focal adhesion]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007187 [G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger]
GO:0007191 [adenylate cyclase-activating dopamine receptor signaling pathway]
GO:0007193 [adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway]
GO:0007194 [negative regulation of adenylate cyclase activity]
GO:0007200 [phospholipase C-activating G-protein coupled receptor signaling pathway]
GO:0007204 [positive regulation of cytosolic calcium ion concentration]
GO:0007218 [neuropeptide signaling pathway]
GO:0007268 [synaptic transmission]
GO:0007600 [sensory perception]
GO:0007626 [locomotory behavior]
GO:0008022 [protein C-terminus binding]
GO:0008285 [negative regulation of cell proliferation]
GO:0009314 [response to radiation]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0019233 [sensory perception of pain]
GO:0019904 [protein domain specific binding]
GO:0030425 [dendrite]
GO:0030818 [negative regulation of cAMP biosynthetic process]
GO:0031005 [filamin binding]
GO:0031635 [adenylate cyclase-inhibiting opioid receptor signaling pathway]
GO:0031681 [G-protein beta-subunit binding]
GO:0032094 [response to food]
GO:0032100 [positive regulation of appetite]
GO:0032496 [response to lipopolysaccharide]
GO:0032590 [dendrite membrane]
GO:0032839 [dendrite cytoplasm]
GO:0033554 [cellular response to stress]
GO:0038003 [opioid receptor signaling pathway]
GO:0038047 [morphine receptor activity]
GO:0042060 [wound healing]
GO:0042220 [response to cocaine]
GO:0042383 [sarcolemma]
GO:0042755 [eating behavior]
GO:0042923 [neuropeptide binding]
GO:0043005 [neuron projection]
GO:0043204 [perikaryon]
GO:0043278 [response to morphine]
GO:0043950 [positive regulation of cAMP-mediated signaling]
GO:0043951 [negative regulation of cAMP-mediated signaling]
GO:0044849 [estrous cycle]
GO:0045019 [negative regulation of nitric oxide biosynthetic process]
GO:0045121 [membrane raft]
GO:0045429 [positive regulation of nitric oxide biosynthetic process]
GO:0045471 [response to ethanol]
GO:0048149 [behavioral response to ethanol]
GO:0050769 [positive regulation of neurogenesis]
GO:0051481 [negative regulation of cytosolic calcium ion concentration]
GO:0051930 [regulation of sensory perception of pain]
GO:0060079 [excitatory postsynaptic potential]
GO:0061358 [negative regulation of Wnt protein secretion]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0070588 [calcium ion transmembrane transport]
GO:0070848 [response to growth factor]
GO:0071315 [cellular response to morphine]
GO:2000310 [regulation of N-methyl-D-aspartate selective glutamate receptor activity]
Show all
 493 aa
55 kDa 		No 7
OPRM1-004
ENSP00000430247
ENST00000520282
E7EW71 [Direct mapping]
Mu-type opioid receptor
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Show all
GO:0004930 [G-protein coupled receptor activity]
GO:0004979 [beta-endorphin receptor activity]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007218 [neuropeptide signaling pathway]
GO:0007268 [synaptic transmission]
GO:0016021 [integral component of membrane]
GO:0019233 [sensory perception of pain]
GO:0031681 [G-protein beta-subunit binding]
GO:0038003 [opioid receptor signaling pathway]
GO:0038047 [morphine receptor activity]
GO:0042923 [neuropeptide binding]
GO:0043005 [neuron projection]
GO:0071315 [cellular response to morphine]
Show all
 163 aa
17.3 kDa 		No 1
OPRM1-005
ENSP00000430876
ENST00000520708
P35372 [Direct mapping]
Mu-type opioid receptor
Show all
G-protein coupled receptors
   GPCRs excl olfactory receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   6TM proteins predicted by MDM
FDA approved drug targets
   Small molecule drugs
Show all
GO:0001965 [G-protein alpha-subunit binding]
GO:0004930 [G-protein coupled receptor activity]
GO:0004979 [beta-endorphin receptor activity]
GO:0005245 [voltage-gated calcium channel activity]
GO:0005515 [protein binding]
GO:0005783 [endoplasmic reticulum]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007187 [G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger]
GO:0007194 [negative regulation of adenylate cyclase activity]
GO:0007200 [phospholipase C-activating G-protein coupled receptor signaling pathway]
GO:0007204 [positive regulation of cytosolic calcium ion concentration]
GO:0007218 [neuropeptide signaling pathway]
GO:0007268 [synaptic transmission]
GO:0007600 [sensory perception]
GO:0008285 [negative regulation of cell proliferation]
GO:0016021 [integral component of membrane]
GO:0019233 [sensory perception of pain]
GO:0031681 [G-protein beta-subunit binding]
GO:0033554 [cellular response to stress]
GO:0038003 [opioid receptor signaling pathway]
GO:0038047 [morphine receptor activity]
GO:0042923 [neuropeptide binding]
GO:0043005 [neuron projection]
GO:0043950 [positive regulation of cAMP-mediated signaling]
GO:0043951 [negative regulation of cAMP-mediated signaling]
GO:0045019 [negative regulation of nitric oxide biosynthetic process]
GO:0045429 [positive regulation of nitric oxide biosynthetic process]
GO:0048149 [behavioral response to ethanol]
GO:0050769 [positive regulation of neurogenesis]
GO:0051481 [negative regulation of cytosolic calcium ion concentration]
GO:0061358 [negative regulation of Wnt protein secretion]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0070588 [calcium ion transmembrane transport]
GO:0071315 [cellular response to morphine]
GO:2000310 [regulation of N-methyl-D-aspartate selective glutamate receptor activity]
Show all
 300 aa
34.4 kDa 		No 6
OPRM1-006
ENSP00000430260
ENST00000518759
P35372 [Direct mapping]
Mu-type opioid receptor
Show all
G-protein coupled receptors
   GPCRs excl olfactory receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   5TM proteins predicted by MDM
FDA approved drug targets
   Small molecule drugs
Show all
GO:0001965 [G-protein alpha-subunit binding]
GO:0004930 [G-protein coupled receptor activity]
GO:0004979 [beta-endorphin receptor activity]
GO:0005245 [voltage-gated calcium channel activity]
GO:0005515 [protein binding]
GO:0005783 [endoplasmic reticulum]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007187 [G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger]
GO:0007194 [negative regulation of adenylate cyclase activity]
GO:0007200 [phospholipase C-activating G-protein coupled receptor signaling pathway]
GO:0007204 [positive regulation of cytosolic calcium ion concentration]
GO:0007218 [neuropeptide signaling pathway]
GO:0007268 [synaptic transmission]
GO:0007600 [sensory perception]
GO:0008285 [negative regulation of cell proliferation]
GO:0016021 [integral component of membrane]
GO:0019233 [sensory perception of pain]
GO:0031681 [G-protein beta-subunit binding]
GO:0033554 [cellular response to stress]
GO:0038003 [opioid receptor signaling pathway]
GO:0038047 [morphine receptor activity]
GO:0042923 [neuropeptide binding]
GO:0043005 [neuron projection]
GO:0043950 [positive regulation of cAMP-mediated signaling]
GO:0043951 [negative regulation of cAMP-mediated signaling]
GO:0045019 [negative regulation of nitric oxide biosynthetic process]
GO:0045429 [positive regulation of nitric oxide biosynthetic process]
GO:0048149 [behavioral response to ethanol]
GO:0050769 [positive regulation of neurogenesis]
GO:0051481 [negative regulation of cytosolic calcium ion concentration]
GO:0061358 [negative regulation of Wnt protein secretion]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0070588 [calcium ion transmembrane transport]
GO:0071315 [cellular response to morphine]
GO:2000310 [regulation of N-methyl-D-aspartate selective glutamate receptor activity]
Show all
 319 aa
36.5 kDa 		No 5
OPRM1-008
ENSP00000338381
ENST00000337049
P35372 [Direct mapping]
Mu-type opioid receptor
Show all
G-protein coupled receptors
   GPCRs excl olfactory receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
FDA approved drug targets
   Small molecule drugs
Show all
GO:0001965 [G-protein alpha-subunit binding]
GO:0004930 [G-protein coupled receptor activity]
GO:0004979 [beta-endorphin receptor activity]
GO:0005245 [voltage-gated calcium channel activity]
GO:0005515 [protein binding]
GO:0005783 [endoplasmic reticulum]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007187 [G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger]
GO:0007194 [negative regulation of adenylate cyclase activity]
GO:0007200 [phospholipase C-activating G-protein coupled receptor signaling pathway]
GO:0007204 [positive regulation of cytosolic calcium ion concentration]
GO:0007218 [neuropeptide signaling pathway]
GO:0007268 [synaptic transmission]
GO:0007600 [sensory perception]
GO:0008285 [negative regulation of cell proliferation]
GO:0016021 [integral component of membrane]
GO:0019233 [sensory perception of pain]
GO:0031681 [G-protein beta-subunit binding]
GO:0033554 [cellular response to stress]
GO:0038003 [opioid receptor signaling pathway]
GO:0038047 [morphine receptor activity]
GO:0042923 [neuropeptide binding]
GO:0043005 [neuron projection]
GO:0043950 [positive regulation of cAMP-mediated signaling]
GO:0043951 [negative regulation of cAMP-mediated signaling]
GO:0045019 [negative regulation of nitric oxide biosynthetic process]
GO:0045429 [positive regulation of nitric oxide biosynthetic process]
GO:0048149 [behavioral response to ethanol]
GO:0050769 [positive regulation of neurogenesis]
GO:0051481 [negative regulation of cytosolic calcium ion concentration]
GO:0061358 [negative regulation of Wnt protein secretion]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0070588 [calcium ion transmembrane transport]
GO:0071315 [cellular response to morphine]
GO:2000310 [regulation of N-methyl-D-aspartate selective glutamate receptor activity]
Show all
 418 aa
47 kDa 		No 7
OPRM1-010
ENSP00000410497
ENST00000452687
P35372 [Direct mapping]
Mu-type opioid receptor
Show all
G-protein coupled receptors
   GPCRs excl olfactory receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
FDA approved drug targets
   Small molecule drugs
Show all
GO:0001965 [G-protein alpha-subunit binding]
GO:0004930 [G-protein coupled receptor activity]
GO:0004979 [beta-endorphin receptor activity]
GO:0005245 [voltage-gated calcium channel activity]
GO:0005515 [protein binding]
GO:0005783 [endoplasmic reticulum]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007187 [G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger]
GO:0007194 [negative regulation of adenylate cyclase activity]
GO:0007200 [phospholipase C-activating G-protein coupled receptor signaling pathway]
GO:0007204 [positive regulation of cytosolic calcium ion concentration]
GO:0007218 [neuropeptide signaling pathway]
GO:0007268 [synaptic transmission]
GO:0007600 [sensory perception]
GO:0008285 [negative regulation of cell proliferation]
GO:0016021 [integral component of membrane]
GO:0019233 [sensory perception of pain]
GO:0031681 [G-protein beta-subunit binding]
GO:0033554 [cellular response to stress]
GO:0038003 [opioid receptor signaling pathway]
GO:0038047 [morphine receptor activity]
GO:0042923 [neuropeptide binding]
GO:0043005 [neuron projection]
GO:0043950 [positive regulation of cAMP-mediated signaling]
GO:0043951 [negative regulation of cAMP-mediated signaling]
GO:0045019 [negative regulation of nitric oxide biosynthetic process]
GO:0045429 [positive regulation of nitric oxide biosynthetic process]
GO:0048149 [behavioral response to ethanol]
GO:0050769 [positive regulation of neurogenesis]
GO:0051481 [negative regulation of cytosolic calcium ion concentration]
GO:0061358 [negative regulation of Wnt protein secretion]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0070588 [calcium ion transmembrane transport]
GO:0071315 [cellular response to morphine]
GO:2000310 [regulation of N-methyl-D-aspartate selective glutamate receptor activity]
Show all
 406 aa
45.5 kDa 		No 7
OPRM1-012
ENSP00000229768
ENST00000229768
P35372 [Direct mapping]
Mu-type opioid receptor
Show all
G-protein coupled receptors
   GPCRs excl olfactory receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
FDA approved drug targets
   Small molecule drugs
Show all
GO:0001965 [G-protein alpha-subunit binding]
GO:0004930 [G-protein coupled receptor activity]
GO:0004979 [beta-endorphin receptor activity]
GO:0005245 [voltage-gated calcium channel activity]
GO:0005515 [protein binding]
GO:0005783 [endoplasmic reticulum]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007187 [G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger]
GO:0007194 [negative regulation of adenylate cyclase activity]
GO:0007200 [phospholipase C-activating G-protein coupled receptor signaling pathway]
GO:0007204 [positive regulation of cytosolic calcium ion concentration]
GO:0007218 [neuropeptide signaling pathway]
GO:0007268 [synaptic transmission]
GO:0007600 [sensory perception]
GO:0008285 [negative regulation of cell proliferation]
GO:0016021 [integral component of membrane]
GO:0019233 [sensory perception of pain]
GO:0031681 [G-protein beta-subunit binding]
GO:0033554 [cellular response to stress]
GO:0038003 [opioid receptor signaling pathway]
GO:0038047 [morphine receptor activity]
GO:0042923 [neuropeptide binding]
GO:0043005 [neuron projection]
GO:0043950 [positive regulation of cAMP-mediated signaling]
GO:0043951 [negative regulation of cAMP-mediated signaling]
GO:0045019 [negative regulation of nitric oxide biosynthetic process]
GO:0045429 [positive regulation of nitric oxide biosynthetic process]
GO:0048149 [behavioral response to ethanol]
GO:0050769 [positive regulation of neurogenesis]
GO:0051481 [negative regulation of cytosolic calcium ion concentration]
GO:0061358 [negative regulation of Wnt protein secretion]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0070588 [calcium ion transmembrane transport]
GO:0071315 [cellular response to morphine]
GO:2000310 [regulation of N-methyl-D-aspartate selective glutamate receptor activity]
Show all
 446 aa
49.5 kDa 		No 7
OPRM1-013
ENSP00000403549
ENST00000419506
P35372 [Direct mapping]
Mu-type opioid receptor
Show all
G-protein coupled receptors
   GPCRs excl olfactory receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
FDA approved drug targets
   Small molecule drugs
Show all
GO:0001965 [G-protein alpha-subunit binding]
GO:0004930 [G-protein coupled receptor activity]
GO:0004979 [beta-endorphin receptor activity]
GO:0005245 [voltage-gated calcium channel activity]
GO:0005515 [protein binding]
GO:0005783 [endoplasmic reticulum]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007187 [G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger]
GO:0007194 [negative regulation of adenylate cyclase activity]
GO:0007200 [phospholipase C-activating G-protein coupled receptor signaling pathway]
GO:0007204 [positive regulation of cytosolic calcium ion concentration]
GO:0007218 [neuropeptide signaling pathway]
GO:0007268 [synaptic transmission]
GO:0007600 [sensory perception]
GO:0008285 [negative regulation of cell proliferation]
GO:0016021 [integral component of membrane]
GO:0019233 [sensory perception of pain]
GO:0031681 [G-protein beta-subunit binding]
GO:0033554 [cellular response to stress]
GO:0038003 [opioid receptor signaling pathway]
GO:0038047 [morphine receptor activity]
GO:0042923 [neuropeptide binding]
GO:0043005 [neuron projection]
GO:0043950 [positive regulation of cAMP-mediated signaling]
GO:0043951 [negative regulation of cAMP-mediated signaling]
GO:0045019 [negative regulation of nitric oxide biosynthetic process]
GO:0045429 [positive regulation of nitric oxide biosynthetic process]
GO:0048149 [behavioral response to ethanol]
GO:0050769 [positive regulation of neurogenesis]
GO:0051481 [negative regulation of cytosolic calcium ion concentration]
GO:0061358 [negative regulation of Wnt protein secretion]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0070588 [calcium ion transmembrane transport]
GO:0071315 [cellular response to morphine]
GO:2000310 [regulation of N-methyl-D-aspartate selective glutamate receptor activity]
Show all
 420 aa
47.1 kDa 		No 7
OPRM1-014
ENSP00000430097
ENST00000524163
P35372 [Direct mapping]
Mu-type opioid receptor
Show all
G-protein coupled receptors
   GPCRs excl olfactory receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
FDA approved drug targets
   Small molecule drugs
Show all
GO:0001965 [G-protein alpha-subunit binding]
GO:0004930 [G-protein coupled receptor activity]
GO:0004979 [beta-endorphin receptor activity]
GO:0005245 [voltage-gated calcium channel activity]
GO:0005515 [protein binding]
GO:0005783 [endoplasmic reticulum]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007187 [G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger]
GO:0007194 [negative regulation of adenylate cyclase activity]
GO:0007200 [phospholipase C-activating G-protein coupled receptor signaling pathway]
GO:0007204 [positive regulation of cytosolic calcium ion concentration]
GO:0007218 [neuropeptide signaling pathway]
GO:0007268 [synaptic transmission]
GO:0007600 [sensory perception]
GO:0008285 [negative regulation of cell proliferation]
GO:0016021 [integral component of membrane]
GO:0019233 [sensory perception of pain]
GO:0031681 [G-protein beta-subunit binding]
GO:0033554 [cellular response to stress]
GO:0038003 [opioid receptor signaling pathway]
GO:0038047 [morphine receptor activity]
GO:0042923 [neuropeptide binding]
GO:0043005 [neuron projection]
GO:0043950 [positive regulation of cAMP-mediated signaling]
GO:0043951 [negative regulation of cAMP-mediated signaling]
GO:0045019 [negative regulation of nitric oxide biosynthetic process]
GO:0045429 [positive regulation of nitric oxide biosynthetic process]
GO:0048149 [behavioral response to ethanol]
GO:0050769 [positive regulation of neurogenesis]
GO:0051481 [negative regulation of cytosolic calcium ion concentration]
GO:0061358 [negative regulation of Wnt protein secretion]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0070588 [calcium ion transmembrane transport]
GO:0071315 [cellular response to morphine]
GO:2000310 [regulation of N-methyl-D-aspartate selective glutamate receptor activity]
Show all
 389 aa
43.6 kDa 		No 7
OPRM1-016
ENSP00000399359
ENST00000414028
P35372 [Direct mapping]
Mu-type opioid receptor
Show all
G-protein coupled receptors
   GPCRs excl olfactory receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
FDA approved drug targets
   Small molecule drugs
Show all
GO:0001965 [G-protein alpha-subunit binding]
GO:0004930 [G-protein coupled receptor activity]
GO:0004979 [beta-endorphin receptor activity]
GO:0005245 [voltage-gated calcium channel activity]
GO:0005515 [protein binding]
GO:0005783 [endoplasmic reticulum]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007187 [G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger]
GO:0007194 [negative regulation of adenylate cyclase activity]
GO:0007200 [phospholipase C-activating G-protein coupled receptor signaling pathway]
GO:0007204 [positive regulation of cytosolic calcium ion concentration]
GO:0007218 [neuropeptide signaling pathway]
GO:0007268 [synaptic transmission]
GO:0007600 [sensory perception]
GO:0008285 [negative regulation of cell proliferation]
GO:0016021 [integral component of membrane]
GO:0019233 [sensory perception of pain]
GO:0031681 [G-protein beta-subunit binding]
GO:0033554 [cellular response to stress]
GO:0038003 [opioid receptor signaling pathway]
GO:0038047 [morphine receptor activity]
GO:0042923 [neuropeptide binding]
GO:0043005 [neuron projection]
GO:0043950 [positive regulation of cAMP-mediated signaling]
GO:0043951 [negative regulation of cAMP-mediated signaling]
GO:0045019 [negative regulation of nitric oxide biosynthetic process]
GO:0045429 [positive regulation of nitric oxide biosynthetic process]
GO:0048149 [behavioral response to ethanol]
GO:0050769 [positive regulation of neurogenesis]
GO:0051481 [negative regulation of cytosolic calcium ion concentration]
GO:0061358 [negative regulation of Wnt protein secretion]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0070588 [calcium ion transmembrane transport]
GO:0071315 [cellular response to morphine]
GO:2000310 [regulation of N-methyl-D-aspartate selective glutamate receptor activity]
Show all
 403 aa
44.9 kDa 		No 7
OPRM1-017
ENSP00000413752
ENST00000435918
P35372 [Direct mapping]
Mu-type opioid receptor
Show all
G-protein coupled receptors
   GPCRs excl olfactory receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
FDA approved drug targets
   Small molecule drugs
Show all
GO:0001965 [G-protein alpha-subunit binding]
GO:0004930 [G-protein coupled receptor activity]
GO:0004979 [beta-endorphin receptor activity]
GO:0005245 [voltage-gated calcium channel activity]
GO:0005515 [protein binding]
GO:0005783 [endoplasmic reticulum]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007187 [G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger]
GO:0007194 [negative regulation of adenylate cyclase activity]
GO:0007200 [phospholipase C-activating G-protein coupled receptor signaling pathway]
GO:0007204 [positive regulation of cytosolic calcium ion concentration]
GO:0007218 [neuropeptide signaling pathway]
GO:0007268 [synaptic transmission]
GO:0007600 [sensory perception]
GO:0008285 [negative regulation of cell proliferation]
GO:0016021 [integral component of membrane]
GO:0019233 [sensory perception of pain]
GO:0031681 [G-protein beta-subunit binding]
GO:0033554 [cellular response to stress]
GO:0038003 [opioid receptor signaling pathway]
GO:0038047 [morphine receptor activity]
GO:0042923 [neuropeptide binding]
GO:0043005 [neuron projection]
GO:0043950 [positive regulation of cAMP-mediated signaling]
GO:0043951 [negative regulation of cAMP-mediated signaling]
GO:0045019 [negative regulation of nitric oxide biosynthetic process]
GO:0045429 [positive regulation of nitric oxide biosynthetic process]
GO:0048149 [behavioral response to ethanol]
GO:0050769 [positive regulation of neurogenesis]
GO:0051481 [negative regulation of cytosolic calcium ion concentration]
GO:0061358 [negative regulation of Wnt protein secretion]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0070588 [calcium ion transmembrane transport]
GO:0071315 [cellular response to morphine]
GO:2000310 [regulation of N-methyl-D-aspartate selective glutamate receptor activity]
Show all
 397 aa
44.7 kDa 		No 7
OPRM1-019
ENSP00000429719
ENST00000522555
P35372 [Direct mapping]
Mu-type opioid receptor
Show all
G-protein coupled receptors
   GPCRs excl olfactory receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   6TM proteins predicted by MDM
FDA approved drug targets
   Small molecule drugs
Show all
GO:0001965 [G-protein alpha-subunit binding]
GO:0004930 [G-protein coupled receptor activity]
GO:0004979 [beta-endorphin receptor activity]
GO:0005245 [voltage-gated calcium channel activity]
GO:0005515 [protein binding]
GO:0005783 [endoplasmic reticulum]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007187 [G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger]
GO:0007194 [negative regulation of adenylate cyclase activity]
GO:0007200 [phospholipase C-activating G-protein coupled receptor signaling pathway]
GO:0007204 [positive regulation of cytosolic calcium ion concentration]
GO:0007218 [neuropeptide signaling pathway]
GO:0007268 [synaptic transmission]
GO:0007600 [sensory perception]
GO:0008285 [negative regulation of cell proliferation]
GO:0016021 [integral component of membrane]
GO:0019233 [sensory perception of pain]
GO:0031681 [G-protein beta-subunit binding]
GO:0033554 [cellular response to stress]
GO:0038003 [opioid receptor signaling pathway]
GO:0038047 [morphine receptor activity]
GO:0042923 [neuropeptide binding]
GO:0043005 [neuron projection]
GO:0043950 [positive regulation of cAMP-mediated signaling]
GO:0043951 [negative regulation of cAMP-mediated signaling]
GO:0045019 [negative regulation of nitric oxide biosynthetic process]
GO:0045429 [positive regulation of nitric oxide biosynthetic process]
GO:0048149 [behavioral response to ethanol]
GO:0050769 [positive regulation of neurogenesis]
GO:0051481 [negative regulation of cytosolic calcium ion concentration]
GO:0061358 [negative regulation of Wnt protein secretion]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0070588 [calcium ion transmembrane transport]
GO:0071315 [cellular response to morphine]
GO:2000310 [regulation of N-methyl-D-aspartate selective glutamate receptor activity]
Show all
 300 aa
34.4 kDa 		No 6
OPRM1-020
ENSP00000429373
ENST00000522236
P35372 [Direct mapping]
Mu-type opioid receptor
Show all
G-protein coupled receptors
   GPCRs excl olfactory receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   6TM proteins predicted by MDM
FDA approved drug targets
   Small molecule drugs
Show all
GO:0001965 [G-protein alpha-subunit binding]
GO:0004930 [G-protein coupled receptor activity]
GO:0004979 [beta-endorphin receptor activity]
GO:0005245 [voltage-gated calcium channel activity]
GO:0005515 [protein binding]
GO:0005783 [endoplasmic reticulum]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007187 [G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger]
GO:0007194 [negative regulation of adenylate cyclase activity]
GO:0007200 [phospholipase C-activating G-protein coupled receptor signaling pathway]
GO:0007204 [positive regulation of cytosolic calcium ion concentration]
GO:0007218 [neuropeptide signaling pathway]
GO:0007268 [synaptic transmission]
GO:0007600 [sensory perception]
GO:0008285 [negative regulation of cell proliferation]
GO:0016021 [integral component of membrane]
GO:0019233 [sensory perception of pain]
GO:0031681 [G-protein beta-subunit binding]
GO:0033554 [cellular response to stress]
GO:0038003 [opioid receptor signaling pathway]
GO:0038047 [morphine receptor activity]
GO:0042923 [neuropeptide binding]
GO:0043005 [neuron projection]
GO:0043950 [positive regulation of cAMP-mediated signaling]
GO:0043951 [negative regulation of cAMP-mediated signaling]
GO:0045019 [negative regulation of nitric oxide biosynthetic process]
GO:0045429 [positive regulation of nitric oxide biosynthetic process]
GO:0048149 [behavioral response to ethanol]
GO:0050769 [positive regulation of neurogenesis]
GO:0051481 [negative regulation of cytosolic calcium ion concentration]
GO:0061358 [negative regulation of Wnt protein secretion]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0070588 [calcium ion transmembrane transport]
GO:0071315 [cellular response to morphine]
GO:2000310 [regulation of N-methyl-D-aspartate selective glutamate receptor activity]
Show all
 300 aa
34.4 kDa 		No 6
OPRM1-201
ENSP00000353598
ENST00000360422
L0E130 [Direct mapping]
Micro opioid receptor isoform hMOR-1A2; Mu-type opioid receptor
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Show all
GO:0004930 [G-protein coupled receptor activity]
GO:0004979 [beta-endorphin receptor activity]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007218 [neuropeptide signaling pathway]
GO:0007268 [synaptic transmission]
GO:0016021 [integral component of membrane]
GO:0019233 [sensory perception of pain]
GO:0031681 [G-protein beta-subunit binding]
GO:0038003 [opioid receptor signaling pathway]
GO:0038047 [morphine receptor activity]
GO:0042923 [neuropeptide binding]
GO:0043005 [neuron projection]
GO:0071315 [cellular response to morphine]
Show all
 476 aa
53.3 kDa 		No 7

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.