Fields »
ABOUT
HELP
BLOG
IL17A

Please wait until image is loaded before changing channels

GENERAL INFORMATION

Gene name

 IL17A

Gene description

 Interleukin 17A

Protein class

 Cancer-related genes
FDA approved drug targets
Plasma proteins
Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 1
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

RNA cell category

 Group enriched (Karpas-707, U-266/84)

Protein evidence

 Evidence at protein level

Main location

 Not available

DATA RELIABILITY

Reliability score

 Pending cell analysis.

ASSAYS
RNA expression

RNA EXPRESSION OVERVIEW
RNA cell line category: Group enriched (Karpas-707, U-266/84)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

GENE INFORMATION

Gene name

 IL17A (HGNC Symbol)

Synonyms

 CTLA8, IL-17, IL-17A, IL17

Description

 Interleukin 17A (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a proinflammatory cytokine produced by activated T cells. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis. [provided by RefSeq, Jul 2008]

Chromosome

 6

Cytoband

 p12.2

Chromosome location (bp)

 52186387 - 52190638

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000112115 (version 83.38)

Entrez gene

 3605

UniProt

 Q16552 (UniProt - Evidence at protein level)

neXtProt

 NX_Q16552

Antibodypedia

 IL17A antibodies

PROTEIN BROWSER
IL17A-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
IL17A-001
ENSP00000344192
ENST00000340057
Q16552 [Direct mapping]
Interleukin-17A
Show all
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
FDA approved drug targets
   Biotech drugs
Show all
GO:0005125 [cytokine activity]
GO:0005126 [cytokine receptor binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005737 [cytoplasm]
GO:0006915 [apoptotic process]
GO:0006954 [inflammatory response]
GO:0006955 [immune response]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007267 [cell-cell signaling]
GO:0008219 [cell death]
GO:0009897 [external side of plasma membrane]
GO:0010940 [positive regulation of necrotic cell death]
GO:0032747 [positive regulation of interleukin-23 production]
GO:0043200 [response to amino acid]
GO:0045672 [positive regulation of osteoclast differentiation]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0050832 [defense response to fungus]
GO:0071347 [cellular response to interleukin-1]
GO:0071385 [cellular response to glucocorticoid stimulus]
GO:0072537 [fibroblast activation]
GO:1900017 [positive regulation of cytokine production involved in inflammatory response]
GO:2000778 [positive regulation of interleukin-6 secretion]
Show all
 155 aa
17.5 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.