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PHACTR1

CANCER ATLAS

Gene description

 Phosphatase and actin regulator 1

Protein class

 Predicted intracellular proteins, Predicted secreted proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA029755
HPA029756
HPA029757

GENE INFORMATION

Gene name

 PHACTR1 (HGNC Symbol)

Synonyms

 dJ257A7.2, KIAA1733, RPEL1

Description

 Phosphatase and actin regulator 1 (HGNC Symbol)

Entrez gene summary

Chromosome

 6

Cytoband

 p24.1

Chromosome location (bp)

 12716805 - 13290484

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000112137 (version 83.38)

Entrez gene

 221692

UniProt

 Q9C0D0 (UniProt - Evidence at transcript level)

neXtProt

 NX_Q9C0D0

Antibodypedia

 PHACTR1 antibodies

PROTEIN BROWSER
PHACTR1-001
PHACTR1-002
PHACTR1-003
PHACTR1-004
PHACTR1-005
PHACTR1-006
PHACTR1-010
PHACTR1-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PHACTR1-001
ENSP00000368655
ENST00000379350
Q9C0D0 [Direct mapping]
Phosphatase and actin regulator 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0004864 [protein phosphatase inhibitor activity]
GO:0005634 [nucleus]
GO:0005829 [cytosol]
GO:0008157 [protein phosphatase 1 binding]
GO:0008599 [protein phosphatase type 1 regulator activity]
GO:0030054 [cell junction]
GO:0031032 [actomyosin structure organization]
GO:0031532 [actin cytoskeleton reorganization]
GO:0043086 [negative regulation of catalytic activity]
GO:0043149 [stress fiber assembly]
GO:0045202 [synapse]
GO:0048870 [cell motility]
Show all
 484 aa
54.6 kDa 		No 0
PHACTR1-002
ENSP00000412573
ENST00000434977
H0Y7G2 [Direct mapping]
Phosphatase and actin regulator
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0004864 [protein phosphatase inhibitor activity]
GO:0008157 [protein phosphatase 1 binding]
GO:0008599 [protein phosphatase type 1 regulator activity]
GO:0031532 [actin cytoskeleton reorganization]
GO:0043086 [negative regulation of catalytic activity]
Show all
 230 aa
25.6 kDa 		No 0
PHACTR1-003
ENSP00000368639
ENST00000379335
Q4VY12 [Direct mapping]
Phosphatase and actin regulator
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0004864 [protein phosphatase inhibitor activity]
GO:0043086 [negative regulation of catalytic activity]
Show all
 144 aa
17.6 kDa 		No 0
PHACTR1-004
ENSP00000368633
ENST00000379329
Q4VY13 [Direct mapping]
Phosphatase and actin regulator
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0004864 [protein phosphatase inhibitor activity]
GO:0043086 [negative regulation of catalytic activity]
Show all
 140 aa
16.7 kDa 		No 0
PHACTR1-005
ENSP00000329880
ENST00000332995
Q9C0D0 [Direct mapping]
Phosphatase and actin regulator 1
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0004864 [protein phosphatase inhibitor activity]
GO:0005634 [nucleus]
GO:0005829 [cytosol]
GO:0008157 [protein phosphatase 1 binding]
GO:0008599 [protein phosphatase type 1 regulator activity]
GO:0030054 [cell junction]
GO:0031032 [actomyosin structure organization]
GO:0031532 [actin cytoskeleton reorganization]
GO:0043086 [negative regulation of catalytic activity]
GO:0043149 [stress fiber assembly]
GO:0045202 [synapse]
GO:0048870 [cell motility]
Show all
 580 aa
66.3 kDa 		No 0
PHACTR1-006
ENSP00000384760
ENST00000406205
H0Y3U1 [Direct mapping]
Phosphatase and actin regulator
Show all
   THUMBUP predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0004864 [protein phosphatase inhibitor activity]
GO:0008157 [protein phosphatase 1 binding]
GO:0008599 [protein phosphatase type 1 regulator activity]
GO:0031532 [actin cytoskeleton reorganization]
GO:0043086 [negative regulation of catalytic activity]
Show all
 265 aa
29.4 kDa 		Yes 0
PHACTR1-010
ENSP00000368653
ENST00000379348
Q5R356 [Direct mapping]
Phosphatase and actin regulator 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 169 aa
18.5 kDa 		No 0
PHACTR1-201
ENSP00000395948
ENST00000415087
H0Y518 [Direct mapping]
Phosphatase and actin regulator
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0004864 [protein phosphatase inhibitor activity]
GO:0008157 [protein phosphatase 1 binding]
GO:0008599 [protein phosphatase type 1 regulator activity]
GO:0031532 [actin cytoskeleton reorganization]
GO:0043086 [negative regulation of catalytic activity]
Show all
 488 aa
55.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.