Expression of RAB23 in cancer - Summary

CANCER ATLAS

Gene description

RAB23, member RAS oncogene family

Protein class

Disease related genes, Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA029135	HPA029136

GENE INFORMATION
Gene name	RAB23
Synonyms
Description	RAB23, member RAS oncogene family (HGNC Symbol)
Entrez gene summary	This gene encodes a small GTPase of the Ras superfamily. Rab proteins are involved in the regulation of diverse cellular functions associated with intracellular membrane trafficking, including autophagy and immune response to bacterial infection. The encoded protein may play a role in central nervous system development by antagonizing sonic hedgehog signaling. Disruption of this gene has been implicated in Carpenter syndrome as well as cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Chromosome	6
Cytoband
Chromosome location (bp)	57186992 - 57222314
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000112210 (version 83.38)
Entrez gene	51715
UniProt	Q9ULC3 (UniProt - Evidence at protein level)
neXtProt	NX_Q9ULC3
Antibodypedia	RAB23 antibodies

PROTEIN BROWSER

RAB23-001	RAB23-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
RAB23-001 ENSP00000320413 ENST00000317483	Q9ULC3 [Direct mapping] Ras-related protein Rab-23 A0A024RD41 [Target identity:100%; Query identity:100%] RAB23, member RAS oncogene family, isoform CRA_a Show all	Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000045 [autophagosome assembly] GO:0003924 [GTPase activity] GO:0005515 [protein binding] GO:0005525 [GTP binding] GO:0005622 [intracellular] GO:0005737 [cytoplasm] GO:0005776 [autophagosome] GO:0005886 [plasma membrane] GO:0006886 [intracellular protein transport] GO:0006913 [nucleocytoplasmic transport] GO:0006968 [cellular defense response] GO:0007165 [signal transduction] GO:0007264 [small GTPase mediated signal transduction] GO:0010008 [endosome membrane] GO:0015031 [protein transport] GO:0016020 [membrane] GO:0030670 [phagocytic vesicle membrane] GO:0032482 [Rab protein signal transduction] GO:0042384 [cilium assembly] GO:0042992 [negative regulation of transcription factor import into nucleus] GO:0045335 [phagocytic vesicle] GO:0070062 [extracellular exosome] GO:0097094 [craniofacial suture morphogenesis] Show all	237 aa 26.7 kDa	No	0
RAB23-201 ENSP00000417610 ENST00000468148	Q9ULC3 [Direct mapping] Ras-related protein Rab-23 A0A024RD41 [Target identity:100%; Query identity:100%] RAB23, member RAS oncogene family, isoform CRA_a Show all	Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000045 [autophagosome assembly] GO:0001843 [neural tube closure] GO:0003924 [GTPase activity] GO:0005515 [protein binding] GO:0005525 [GTP binding] GO:0005622 [intracellular] GO:0005737 [cytoplasm] GO:0005776 [autophagosome] GO:0005886 [plasma membrane] GO:0006886 [intracellular protein transport] GO:0006913 [nucleocytoplasmic transport] GO:0006968 [cellular defense response] GO:0007165 [signal transduction] GO:0007264 [small GTPase mediated signal transduction] GO:0007399 [nervous system development] GO:0008589 [regulation of smoothened signaling pathway] GO:0010008 [endosome membrane] GO:0015031 [protein transport] GO:0016020 [membrane] GO:0021513 [spinal cord dorsal/ventral patterning] GO:0030670 [phagocytic vesicle membrane] GO:0032482 [Rab protein signal transduction] GO:0042384 [cilium assembly] GO:0042733 [embryonic digit morphogenesis] GO:0042992 [negative regulation of transcription factor import into nucleus] GO:0045335 [phagocytic vesicle] GO:0045861 [negative regulation of proteolysis] GO:0070062 [extracellular exosome] GO:0097094 [craniofacial suture morphogenesis] Show all	237 aa 26.7 kDa	No	0