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Strong staining was observed in a few cases of malignant gliomas. A majority of breast, prostate, gastric, pancreatic and liver cancers displayed moderate immunoreactivity. Remaining malignant cells were in general weakly stained or negative.
GENE INFORMATION
Gene name
CCNC (HGNC Symbol)
Synonyms
CycC
Description
Cyclin C (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene is a member of the cyclin family of proteins. The encoded protein interacts with cyclin-dependent kinase 8 and induces the phophorylation of the carboxy-terminal domain of the large subunit of RNA polymerase II. The level of mRNAs for this gene peaks in the G1 phase of the cell cycle. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000151 [ubiquitin ligase complex] GO:0000307 [cyclin-dependent protein kinase holoenzyme complex] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0006351 [transcription, DNA-templated] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0007179 [transforming growth factor beta receptor signaling pathway] GO:0007219 [Notch signaling pathway] GO:0010467 [gene expression] GO:0016538 [cyclin-dependent protein serine/threonine kinase regulator activity] GO:0016567 [protein ubiquitination] GO:0016592 [mediator complex] GO:0019901 [protein kinase binding] GO:0045737 [positive regulation of cyclin-dependent protein serine/threonine kinase activity] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0061630 [ubiquitin protein ligase activity] GO:0090209 [negative regulation of triglyceride metabolic process] GO:1901409 [positive regulation of phosphorylation of RNA polymerase II C-terminal domain]
SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000307 [cyclin-dependent protein kinase holoenzyme complex] GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0006351 [transcription, DNA-templated] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0007179 [transforming growth factor beta receptor signaling pathway] GO:0007219 [Notch signaling pathway] GO:0010467 [gene expression] GO:0016538 [cyclin-dependent protein serine/threonine kinase regulator activity] GO:0019901 [protein kinase binding] GO:0045737 [positive regulation of cyclin-dependent protein serine/threonine kinase activity] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:1901409 [positive regulation of phosphorylation of RNA polymerase II C-terminal domain]