Cell atlas - SIM1 - The Human Protein Atlas

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SIM1

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nuclear speckles

Human cell
	Nucleoplasm

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GENERAL INFORMATION
Gene name	SIM1
Gene description	Single-minded family bHLH transcription factor 1
Protein class	Plasma proteins Predicted intracellular proteins Transcription factors
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the nuclear speckles.
RNA cell category	Cell line enhanced (BJ hTERT+, RPTEC TERT1, BJ)
Protein evidence	Evidence at transcript level
Main location	Localized to the Nuclear speckles (approved)
Single-cell variation	Single-cell variation in protein expression observed.

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA024385
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (BJ hTERT+, RPTEC TERT1, BJ) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the nuclear speckles.

Main location

Nuclear speckles (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA024385	BJ	Nuclear speckles	Intensity
	HPA024385	HEK 293	Nuclear speckles	Intensity

GENE INFORMATION
Gene name	SIM1 (HGNC Symbol)
Synonyms	bHLHe14
Description	Single-minded family bHLH transcription factor 1 (HGNC Symbol)
Entrez gene summary	SIM1 and SIM2 genes are Drosophila single-minded (sim) gene homologs. SIM1 transcript was detected only in fetal kidney out of various adult and fetal tissues tested. Since the sim gene plays an important role in Drosophila development and has peak levels of expression during the period of neurogenesis,it was proposed that the human SIM gene is a candidate for involvement in certain dysmorphic features (particularly the facial and skull characteristics), abnormalities of brain development, and/or mental retardation of Down syndrome. [provided by RefSeq, Jul 2008]
Chromosome	6
Cytoband	q16.3
Chromosome location (bp)	100385015 - 100464929
Protein evidence	Evidence at transcript level (all genes)
Ensembl	ENSG00000112246 (version 83.38)
Entrez gene	6492
UniProt	P81133 (UniProt - Evidence at transcript level)
neXtProt	NX_P81133
Antibodypedia	SIM1 antibodies

PROTEIN BROWSER

SIM1-001	SIM1-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SIM1-001 ENSP00000358210 ENST00000369208	P81133 [Direct mapping] Single-minded homolog 1 Show all	Predicted intracellular proteins Plasma proteins Transcription factors Basic domains Show all	GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding] GO:0001657 [ureteric bud development] GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0007399 [nervous system development] GO:0030154 [cell differentiation] GO:0046982 [protein heterodimerization activity] GO:0046983 [protein dimerization activity] Show all	766 aa 85.5 kDa	No	0
SIM1-201 ENSP00000262901 ENST00000262901	P81133 [Direct mapping] Single-minded homolog 1 Show all	Predicted intracellular proteins Plasma proteins Transcription factors Basic domains Show all	GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding] GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0007399 [nervous system development] GO:0030154 [cell differentiation] GO:0046983 [protein dimerization activity] Show all	766 aa 85.5 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.