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Renal cancers along with several cases of liver and endometrial cancers and glioma showed moderate to strong staining. A majority of cancer tissues showed weak cytoplasmic staining or were negative.
Glycosylphosphatidylinositol specific phospholipase D1 (HGNC Symbol)
Entrez gene summary
Many proteins are tethered to the extracellular face of eukaryotic plasma membranes by a glycosylphosphatidylinositol (GPI) anchor. The GPI-anchor is a glycolipid found on many blood cells. The protein encoded by this gene is a GPI degrading enzyme. Glycosylphosphatidylinositol specific phospholipase D1 hydrolyzes the inositol phosphate linkage in proteins anchored by phosphatidylinositol glycans, thereby releasing the attached protein from the plasma membrane. [provided by RefSeq, Jul 2008]