Expression of RPS12 in cancer - Summary

CANCER ATLAS

Gene description

Ribosomal protein S12

Protein class

Plasma proteins, Predicted intracellular proteins, Ribosomal proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA006124

GENE INFORMATION
Gene name	RPS12 (HGNC Symbol)
Synonyms	S12
Description	Ribosomal protein S12 (HGNC Symbol)
Entrez gene summary	Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S12E family of ribosomal proteins. It is located in the cytoplasm. Increased expression of this gene in colorectal cancers compared to matched normal colonic mucosa has been observed. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]
Chromosome	6
Cytoband	q23.2
Chromosome location (bp)	132814441 - 132817564
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000112306 (version 83.38)
Entrez gene	6206
UniProt	P25398 (UniProt - Evidence at protein level)
neXtProt	NX_P25398
Antibodypedia	RPS12 antibodies

PROTEIN BROWSER

RPS12-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
RPS12-001 ENSP00000230050 ENST00000230050	P25398 [Direct mapping] 40S ribosomal protein S12 Show all	Ribosomal proteins Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000184 [nuclear-transcribed mRNA catabolic process, nonsense-mediated decay] GO:0003735 [structural constituent of ribosome] GO:0005622 [intracellular] GO:0005829 [cytosol] GO:0005840 [ribosome] GO:0006412 [translation] GO:0006413 [translational initiation] GO:0006414 [translational elongation] GO:0006415 [translational termination] GO:0006614 [SRP-dependent cotranslational protein targeting to membrane] GO:0010467 [gene expression] GO:0016020 [membrane] GO:0016032 [viral process] GO:0019058 [viral life cycle] GO:0019083 [viral transcription] GO:0022627 [cytosolic small ribosomal subunit] GO:0044267 [cellular protein metabolic process] GO:0044822 [poly(A) RNA binding] Show all	132 aa 14.5 kDa	No	0