Expression of FIG4 in cancer - Summary - The Human Protein Atlas

CANCER ATLAS

Gene description

FIG4 phosphoinositide 5-phosphatase

Protein class

Disease related genes, Predicted intracellular proteins, Predicted membrane proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

CAB017823

GENE INFORMATION
Gene name	FIG4 (HGNC Symbol)
Synonyms	ALS11, CMT4J, dJ249I4.1, hSac3, KIAA0274, SAC3
Description	FIG4 phosphoinositide 5-phosphatase (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene belongs to the SAC domain-containing protein gene family. The SAC domain, approximately 400 amino acids in length and consisting of seven conserved motifs, has been shown to possess phosphoinositide phosphatase activity. The yeast homolog, Sac1p, is involved in the regulation of various phosphoinositides, and affects diverse cellular functions such as actin cytoskeleton organization, Golgi function, and maintenance of vacuole morphology. Membrane-bound phosphoinositides function as signaling molecules and play a key role in vesicle trafficking in eukaryotic cells. Mutations in this gene have been associated with Charcot-Marie-Tooth disease, type 4J. [provided by RefSeq, Jul 2008]
Chromosome	6
Cytoband	q21
Chromosome location (bp)	109691312 - 109825428
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000112367 (version 83.38)
Entrez gene	9896
UniProt	Q92562 (UniProt - Evidence at protein level)
neXtProt	NX_Q92562
Antibodypedia	FIG4 antibodies

PROTEIN BROWSER

FIG4-001	FIG4-002	FIG4-003	FIG4-004	FIG4-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
FIG4-001 ENSP00000230124 ENST00000230124	Q92562 [Direct mapping] Polyphosphoinositide phosphatase Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0004438 [phosphatidylinositol-3-phosphatase activity] GO:0005515 [protein binding] GO:0005783 [endoplasmic reticulum] GO:0005794 [Golgi apparatus] GO:0006644 [phospholipid metabolic process] GO:0006661 [phosphatidylinositol biosynthetic process] GO:0007033 [vacuole organization] GO:0007626 [locomotory behavior] GO:0010008 [endosome membrane] GO:0010976 [positive regulation of neuron projection development] GO:0016311 [dephosphorylation] GO:0031642 [negative regulation of myelination] GO:0031901 [early endosome membrane] GO:0031902 [late endosome membrane] GO:0032288 [myelin assembly] GO:0034593 [phosphatidylinositol bisphosphate phosphatase activity] GO:0036092 [phosphatidylinositol-3-phosphate biosynthetic process] GO:0042578 [phosphoric ester hydrolase activity] GO:0043473 [pigmentation] GO:0043812 [phosphatidylinositol-4-phosphate phosphatase activity] GO:0043813 [phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity] GO:0044281 [small molecule metabolic process] GO:0046488 [phosphatidylinositol metabolic process] GO:0048666 [neuron development] GO:0055037 [recycling endosome] Show all	907 aa 103.6 kDa	No	1
FIG4-002 ENSP00000405660 ENST00000415980	H0Y6G7 [Direct mapping] Polyphosphoinositide phosphatase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		136 aa 16 kDa	No	0
FIG4-003 ENSP00000396566 ENST00000419951	Q5JRV4 [Direct mapping] Polyphosphoinositide phosphatase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		99 aa 10.5 kDa	No	0
FIG4-004 ENSP00000412156 ENST00000454215	Q5TCS5 [Direct mapping] Polyphosphoinositide phosphatase Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0008152 [metabolic process] GO:0016021 [integral component of membrane] GO:0042578 [phosphoric ester hydrolase activity] Show all	237 aa 27.5 kDa	No	1
FIG4-005 ENSP00000357937 ENST00000368941	Q5TCS4 [Direct mapping] Polyphosphoinositide phosphatase Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0008152 [metabolic process] GO:0016021 [integral component of membrane] GO:0042578 [phosphoric ester hydrolase activity] Show all	139 aa 15.9 kDa	No	1