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CCR6

CANCER ATLAS

Gene description

 Chemokine (C-C motif) receptor 6

Protein class

 CD markers, G-protein coupled receptors, Predicted membrane proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA014488
CAB006820

GENE INFORMATION

Gene name

 CCR6 (HGNC Symbol)

Synonyms

 BN-1, CD196, CKR-L3, CMKBR6, DCR2, DRY-6, GPR-CY4, GPR29, STRL22

Description

 Chemokine (C-C motif) receptor 6 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. The gene is preferentially expressed by immature dendritic cells and memory T cells. The ligand of this receptor is macrophage inflammatory protein 3 alpha (MIP-3 alpha). This receptor has been shown to be important for B-lineage maturation and antigen-driven B-cell differentiation, and it may regulate the migration and recruitment of dentritic and T cells during inflammatory and immunological responses. Alternatively spliced transcript variants that encode the same protein have been described for this gene. [provided by RefSeq, Jul 2008]

Chromosome

 6

Cytoband

 q27

Chromosome location (bp)

 167111807 - 167139696

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000112486 (version 83.38)

Entrez gene

 1235

UniProt

 P51684 (UniProt - Evidence at transcript level)

neXtProt

 NX_P51684

Antibodypedia

 CCR6 antibodies

PROTEIN BROWSER
CCR6-001
CCR6-002
CCR6-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CCR6-001
ENSP00000339393
ENST00000349984
P51684 [Direct mapping]
C-C chemokine receptor type 6
Show all
CD markers
G-protein coupled receptors
   GPCRs excl olfactory receptors
   Chemokines and chemotactic factors receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Show all
GO:0002407 [dendritic cell chemotaxis]
GO:0004872 [receptor activity]
GO:0004930 [G-protein coupled receptor activity]
GO:0004950 [chemokine receptor activity]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006928 [movement of cell or subcellular component]
GO:0006935 [chemotaxis]
GO:0006955 [immune response]
GO:0006959 [humoral immune response]
GO:0006968 [cellular defense response]
GO:0007165 [signal transduction]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0016021 [integral component of membrane]
GO:0016493 [C-C chemokine receptor activity]
GO:0045087 [innate immune response]
GO:0070098 [chemokine-mediated signaling pathway]
Show all
 374 aa
42.5 kDa 		No 7
CCR6-002
ENSP00000343952
ENST00000341935
P51684 [Direct mapping]
C-C chemokine receptor type 6
Show all
CD markers
G-protein coupled receptors
   GPCRs excl olfactory receptors
   Chemokines and chemotactic factors receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Show all
GO:0002407 [dendritic cell chemotaxis]
GO:0004872 [receptor activity]
GO:0004930 [G-protein coupled receptor activity]
GO:0004950 [chemokine receptor activity]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006928 [movement of cell or subcellular component]
GO:0006935 [chemotaxis]
GO:0006955 [immune response]
GO:0006959 [humoral immune response]
GO:0006968 [cellular defense response]
GO:0007165 [signal transduction]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007204 [positive regulation of cytosolic calcium ion concentration]
GO:0009986 [cell surface]
GO:0010634 [positive regulation of epithelial cell migration]
GO:0016021 [integral component of membrane]
GO:0016493 [C-C chemokine receptor activity]
GO:0045087 [innate immune response]
GO:0070098 [chemokine-mediated signaling pathway]
GO:2000510 [positive regulation of dendritic cell chemotaxis]
Show all
 374 aa
42.5 kDa 		No 7
CCR6-201
ENSP00000383715
ENST00000400926
P51684 [Direct mapping]
C-C chemokine receptor type 6
Show all
CD markers
G-protein coupled receptors
   GPCRs excl olfactory receptors
   Chemokines and chemotactic factors receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Show all
GO:0002407 [dendritic cell chemotaxis]
GO:0004872 [receptor activity]
GO:0004930 [G-protein coupled receptor activity]
GO:0004950 [chemokine receptor activity]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006928 [movement of cell or subcellular component]
GO:0006935 [chemotaxis]
GO:0006955 [immune response]
GO:0006959 [humoral immune response]
GO:0006968 [cellular defense response]
GO:0007165 [signal transduction]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0016021 [integral component of membrane]
GO:0016493 [C-C chemokine receptor activity]
GO:0045087 [innate immune response]
GO:0070098 [chemokine-mediated signaling pathway]
Show all
 374 aa
42.5 kDa 		No 7

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.