Expression of SLC22A2 in cancer - Summary

CANCER ATLAS

Gene description

Solute carrier family 22 (organic cation transporter), member 2

Protein class

Predicted membrane proteins, Transporters

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Renal cancer

STAINING SUMMARY

HPA008567	CAB068236	CAB068237

GENE INFORMATION
Gene name	SLC22A2 (HGNC Symbol)
Synonyms	OCT2
Description	Solute carrier family 22 (organic cation transporter), member 2 (HGNC Symbol)
Entrez gene summary	Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. This gene is one of three similar cation transporter genes located in a cluster on chromosome 6. The encoded protein contains twelve putative transmembrane domains and is a plasma integral membrane protein. It is found primarily in the kidney, where it may mediate the first step in cation reabsorption. [provided by RefSeq, Jul 2008]
Chromosome	6
Cytoband	q25.3
Chromosome location (bp)	160171061 - 160277638
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000112499 (version 83.38)
Entrez gene	6582
UniProt	O15244 (UniProt - Evidence at protein level)
neXtProt	NX_O15244
Antibodypedia	SLC22A2 antibodies

PROTEIN BROWSER

SLC22A2-001	SLC22A2-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SLC22A2-001 ENSP00000355920 ENST00000366953	O15244 [Direct mapping] Solute carrier family 22 member 2 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Kim et al 2014) Show all	GO:0005215 [transporter activity] GO:0005329 [dopamine transmembrane transporter activity] GO:0005496 [steroid binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006812 [cation transport] GO:0006855 [drug transmembrane transport] GO:0007268 [synaptic transmission] GO:0007269 [neurotransmitter secretion] GO:0007589 [body fluid secretion] GO:0015075 [ion transmembrane transporter activity] GO:0015101 [organic cation transmembrane transporter activity] GO:0015220 [choline transmembrane transporter activity] GO:0015651 [quaternary ammonium group transmembrane transporter activity] GO:0015695 [organic cation transport] GO:0015697 [quaternary ammonium group transport] GO:0015871 [choline transport] GO:0015872 [dopamine transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016323 [basolateral plasma membrane] GO:0022857 [transmembrane transporter activity] GO:0034220 [ion transmembrane transport] GO:0042136 [neurotransmitter biosynthetic process] GO:0044281 [small molecule metabolic process] GO:0051608 [histamine transport] GO:0055085 [transmembrane transport] GO:0070062 [extracellular exosome] GO:0072488 [ammonium transmembrane transport] Show all	555 aa 62.6 kDa	No	>9
SLC22A2-003 ENSP00000355919 ENST00000366952	Q5T7Q5 [Direct mapping] Solute carrier family 22 member 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 5TM proteins predicted by MDM Show all	GO:0005215 [transporter activity] GO:0016021 [integral component of membrane] GO:0022857 [transmembrane transporter activity] GO:0055085 [transmembrane transport] Show all	334 aa 37.9 kDa	No	5