Expression of EXOC2 in cancer - Summary

CANCER ATLAS

Gene description

Exocyst complex component 2

Protein class

Predicted intracellular proteins, RAS pathway related proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA032093

GENE INFORMATION
Gene name	EXOC2 (HGNC Symbol)
Synonyms	FLJ11026, SEC5L1, Sec5p
Description	Exocyst complex component 2 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a component of the exocyst complex, a multi-protein complex essential for the polarized targeting of exocytic vesicles to specific docking sites on the plasma membrane. Though best characterized in yeast, the component proteins and the functions of the exocyst complex have been demonstrated to be highly conserved in higher eukaryotes. At least eight components of the exocyst complex, including this protein, are found to interact with the actin cytoskeletal remodeling and vesicle transport machinery. This interaction has been shown to mediate filopodia formation in fibroblasts. This protein has been shown to interact with the Ral subfamily of GTPases and thereby mediate exocytosis by tethering vesicles to the plasma membrane. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012]
Chromosome	6
Cytoband	p25.3
Chromosome location (bp)	485133 - 693111
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000112685 (version 83.38)
Entrez gene	55770
UniProt	Q96KP1 (UniProt - Evidence at protein level)
neXtProt	NX_Q96KP1
Antibodypedia	EXOC2 antibodies

PROTEIN BROWSER

EXOC2-002	EXOC2-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
EXOC2-002 ENSP00000230449 ENST00000230449	Q96KP1 [Direct mapping] Exocyst complex component 2 A0A024QZT2 [Target identity:100%; Query identity:100%] Exocyst complex component 2, isoform CRA_a Show all	Predicted intracellular proteins RAS pathway related proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000145 [exocyst] GO:0001927 [exocyst assembly] GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0006893 [Golgi to plasma membrane transport] GO:0006996 [organelle organization] GO:0015031 [protein transport] GO:0016020 [membrane] GO:0017160 [Ral GTPase binding] GO:0019901 [protein kinase binding] GO:0043231 [intracellular membrane-bounded organelle] GO:0044267 [cellular protein metabolic process] GO:0047485 [protein N-terminus binding] GO:0061024 [membrane organization] GO:2000535 [regulation of entry of bacterium into host cell] Show all	924 aa 104.1 kDa	No	0
EXOC2-003 ENSP00000406400 ENST00000443083	Q2MDF5 [Direct mapping] Exocyst complex component 2 Show all	Predicted intracellular proteins RAS pathway related proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000145 [exocyst] GO:0005515 [protein binding] GO:0006893 [Golgi to plasma membrane transport] Show all	140 aa 15.2 kDa	No	0