Tissue expression of BTN2A1 - Summary - The Human Protein Atlas

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BTN2A1

TISSUE

CELL

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	BTN2A1
Gene description	Butyrophilin, subfamily 2, member A1
Protein class	Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Expressed in all
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

Protein expression

General cytoplasmic expression, including membranous expression in several tissues.

DATA RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA019208
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	BTN2A1 (HGNC Symbol)
Synonyms	BT2.1, BTF1, BTN2.1
Description	Butyrophilin, subfamily 2, member A1 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the immunoglobulin superfamily. The gene is located in a cluster of butyrophilin-like genes in the juxta-telomeric region of the major histocompatibility complex on chromosome 6. A pseudogene of this gene has been identified in this cluster. The encoded protein is an integral plasma membrane protein involved in lipid, fatty-acid, and sterol metabolism. Alterations in this gene may be associated with several disease states including metabolic syndrome. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2013]
Chromosome	6
Cytoband	p22.2
Chromosome location (bp)	26457904 - 26476621
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000112763 (version 83.38)
Entrez gene	11120
UniProt	Q7KYR7 (UniProt - Evidence at protein level)
neXtProt	NX_Q7KYR7
Antibodypedia	BTN2A1 antibodies

PROTEIN BROWSER

BTN2A1-001	BTN2A1-003	BTN2A1-004	BTN2A1-006	BTN2A1-007	BTN2A1-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
BTN2A1-001 ENSP00000312158 ENST00000312541	Q7KYR7 [Direct mapping] Butyrophilin subfamily 2 member A1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003674 [molecular_function] GO:0005515 [protein binding] GO:0005887 [integral component of plasma membrane] GO:0006629 [lipid metabolic process] GO:0070062 [extracellular exosome] Show all	527 aa 59.6 kDa	Yes	1
BTN2A1-003 ENSP00000416945 ENST00000429381	Q7KYR7 [Direct mapping] Butyrophilin subfamily 2 member A1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003674 [molecular_function] GO:0005515 [protein binding] GO:0005887 [integral component of plasma membrane] GO:0006629 [lipid metabolic process] GO:0070062 [extracellular exosome] Show all	334 aa 37.9 kDa	Yes	1
BTN2A1-004 ENSP00000419043 ENST00000469185	Q7KYR7 [Direct mapping] Butyrophilin subfamily 2 member A1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003674 [molecular_function] GO:0005515 [protein binding] GO:0005887 [integral component of plasma membrane] GO:0006629 [lipid metabolic process] GO:0070062 [extracellular exosome] Show all	330 aa 37.2 kDa	Yes	1
BTN2A1-006 ENSP00000420447 ENST00000493173	C9JNC3 [Direct mapping] Butyrophilin subfamily 2 member A1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	86 aa 9.9 kDa	No	0
BTN2A1-007 ENSP00000418936 ENST00000480218	H7C542 [Direct mapping] Butyrophilin subfamily 2 member A1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all		78 aa 9.4 kDa	No	1
BTN2A1-201 ENSP00000443909 ENST00000541522	Q7KYR7 [Direct mapping] Butyrophilin subfamily 2 member A1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003674 [molecular_function] GO:0005515 [protein binding] GO:0005887 [integral component of plasma membrane] GO:0006629 [lipid metabolic process] GO:0070062 [extracellular exosome] Show all	466 aa 53.2 kDa	No	1

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The Human Protein Atlas

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