Fields »
ABOUT
HELP
BLOG
CLIC5

Please wait until image is loaded before changing channels

GENERAL INFORMATION

Gene name

 CLIC5

Gene description

 Chloride intracellular channel 5

Protein class

 Disease related genes
Potential drug targets
Predicted intracellular proteins
Transporters

Predicted localization

 Intracellular

Number of transcripts

 3
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to the plasma membrane. In addition localized to the nuclear speckles.

RNA cell category

 Group enriched (REH, CAPAN-2, U-266/70, EFO-21, HDLM-2)

Protein evidence

 Evidence at protein level

Main location

 Localized to the Plasma membrane (supported)

Additional location

 In addition localized to the Nuclear speckles (approved)

DATA RELIABILITY

Reliability score

 Supported based on 1 antibody.
HPA074371
SHOW MORE

ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Group enriched (REH, CAPAN-2, U-266/70, EFO-21, HDLM-2)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Mainly localized to the plasma membrane. In addition localized to the nuclear speckles.

Main location

 Plasma membrane (supported)

Additional location

 Nuclear speckles (approved)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA074371 A-431 Nuclear speckles
Plasma membrane
HPA074371 REH Nuclear speckles
Plasma membrane
HPA074371 U-2 OS Nuclear speckles
Plasma membrane

GENE INFORMATION

Gene name

 CLIC5 (HGNC Symbol)

Synonyms

 DFNB102

Description

 Chloride intracellular channel 5 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the chloride intracellular channel (CLIC) family of chloride ion channels. The encoded protein associates with actin-based cytoskeletal structures and may play a role in multiple processes including hair cell stereocilia formation, myoblast proliferation and glomerular podocyte and endothelial cell maintenance. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]

Chromosome

 6

Cytoband

 p21.1

Chromosome location (bp)

 45898451 - 46080395

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000112782 (version 83.38)

Entrez gene

 53405

UniProt

 Q9NZA1 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9NZA1

Antibodypedia

 CLIC5 antibodies

PROTEIN BROWSER
CLIC5-002
CLIC5-003
CLIC5-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CLIC5-002
ENSP00000185206
ENST00000185206
Q9NZA1 [Direct mapping]
Chloride intracellular channel protein 5
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002021 [response to dietary excess]
GO:0002024 [diet induced thermogenesis]
GO:0005244 [voltage-gated ion channel activity]
GO:0005254 [chloride channel activity]
GO:0005515 [protein binding]
GO:0005794 [Golgi apparatus]
GO:0005815 [microtubule organizing center]
GO:0005938 [cell cortex]
GO:0006810 [transport]
GO:0006821 [chloride transport]
GO:0007565 [female pregnancy]
GO:0007605 [sensory perception of sound]
GO:0008104 [protein localization]
GO:0015629 [actin cytoskeleton]
GO:0032420 [stereocilium]
GO:0032421 [stereocilium bundle]
GO:0034707 [chloride channel complex]
GO:0034765 [regulation of ion transmembrane transport]
GO:0050885 [neuromuscular process controlling balance]
GO:0060088 [auditory receptor cell stereocilium organization]
GO:0070062 [extracellular exosome]
GO:1902476 [chloride transmembrane transport]
Show all
 410 aa
46.5 kDa 		No 0
CLIC5-003
ENSP00000344165
ENST00000339561
Q9NZA1 [Direct mapping]
Chloride intracellular channel protein 5
Q53G01 [Target identity:100%; Query identity:100%]
Chloride intracellular channel protein
Show all
Transporters
   Transporter channels and pores
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005244 [voltage-gated ion channel activity]
GO:0005254 [chloride channel activity]
GO:0005515 [protein binding]
GO:0005794 [Golgi apparatus]
GO:0005815 [microtubule organizing center]
GO:0005938 [cell cortex]
GO:0006810 [transport]
GO:0006821 [chloride transport]
GO:0007565 [female pregnancy]
GO:0007605 [sensory perception of sound]
GO:0015629 [actin cytoskeleton]
GO:0034707 [chloride channel complex]
GO:0034765 [regulation of ion transmembrane transport]
GO:0060088 [auditory receptor cell stereocilium organization]
GO:0070062 [extracellular exosome]
GO:1902476 [chloride transmembrane transport]
Show all
 251 aa
28.2 kDa 		No 0
CLIC5-201
ENSP00000439195
ENST00000544153
Q9NZA1 [Direct mapping]
Chloride intracellular channel protein 5
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005244 [voltage-gated ion channel activity]
GO:0005254 [chloride channel activity]
GO:0005515 [protein binding]
GO:0005794 [Golgi apparatus]
GO:0005815 [microtubule organizing center]
GO:0005938 [cell cortex]
GO:0006810 [transport]
GO:0006821 [chloride transport]
GO:0007565 [female pregnancy]
GO:0007605 [sensory perception of sound]
GO:0015629 [actin cytoskeleton]
GO:0034707 [chloride channel complex]
GO:0034765 [regulation of ion transmembrane transport]
GO:0060088 [auditory receptor cell stereocilium organization]
GO:0070062 [extracellular exosome]
GO:1902476 [chloride transmembrane transport]
Show all
 205 aa
22.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.