Expression of PRSS16 in cancer - Summary

CANCER ATLAS

Gene description

Protease, serine, 16 (thymus)

Protein class

Enzymes, Predicted intracellular proteins, Predicted secreted proteins

Protein evidence

Evidence at transcript level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA017743

GENE INFORMATION
Gene name	PRSS16 (HGNC Symbol)
Synonyms	TSSP
Description	Protease, serine, 16 (thymus) (HGNC Symbol)
Entrez gene summary	This gene encodes a serine protease expressed exclusively in the thymus. It is thought to play a role in the alternative antigen presenting pathway used by cortical thymic epithelial cells during the positive selection of T cells. The gene is found in the large histone gene cluster on chromosome 6, near the major histocompatibility complex (MHC) class I region. A second transcript variant has been described, but its full length nature has not been determined. [provided by RefSeq, Jul 2008]
Chromosome	6
Cytoband	p22.1
Chromosome location (bp)	27247701 - 27256624
Protein evidence	Evidence at transcript level (all genes)
Ensembl	ENSG00000112812 (version 83.38)
Entrez gene	10279
UniProt	Q9NQE7 (UniProt - Evidence at transcript level)
neXtProt	NX_Q9NQE7
Antibodypedia	PRSS16 antibodies

PROTEIN BROWSER

PRSS16-001	PRSS16-002	PRSS16-006	PRSS16-007

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PRSS16-001 ENSP00000230582 ENST00000230582	Q9NQE7 [Direct mapping] Thymus-specific serine protease Show all	Enzymes Peptidases Serine-type peptidases MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0005764 [lysosome] GO:0005768 [endosome] GO:0006508 [proteolysis] GO:0008236 [serine-type peptidase activity] GO:0016023 [cytoplasmic membrane-bounded vesicle] GO:0030163 [protein catabolic process] Show all	514 aa 55 kDa	Yes	0
PRSS16-002 ENSP00000404349 ENST00000421826	F2Z2N5 [Direct mapping] Thymus-specific serine protease Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Phobius predicted secreted proteins Predicted intracellular proteins Show all	GO:0006508 [proteolysis] GO:0008236 [serine-type peptidase activity] Show all	257 aa 28.1 kDa	No	0
PRSS16-006 ENSP00000418710 ENST00000485993	H0Y893 [Direct mapping] Thymus-specific serine protease Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Show all	GO:0006508 [proteolysis] GO:0008236 [serine-type peptidase activity] Show all	139 aa 15 kDa	No	0
PRSS16-007 ENSP00000419538 ENST00000475106	H0Y8B9 [Direct mapping] Thymus-specific serine protease Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Show all	GO:0006508 [proteolysis] GO:0008236 [serine-type peptidase activity] Show all	165 aa 17.8 kDa	No	0