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Cancer tissues showed weak immunoreactivity or were negative. Several cases of gastric, pancreatic, liver, endometrial, ovarian, cervical and breast cancers showed cases of strong cytoplasmic positivity.
Cancer cells showed weak to moderate granular cytoplasmic staining. Colorectal cancers in general and cases of gliomas, lymphomas, pancreatic, cervical, ovarian and endometrial cancers showed strong cytoplasmic staining.
GENE INFORMATION
Gene name
MAN2A1 (HGNC Symbol)
Synonyms
GOLIM7, MANA2
Description
Mannosidase, alpha, class 2A, member 1 (HGNC Symbol)
Entrez gene summary
This gene encodes a glycosyl hydrolase that localizes to the Golgi and catalyzes the final hydrolytic step in the asparagine-linked oligosaccharide (N-glycan) maturation pathway. Mutations in the mouse homolog of this gene have been shown to cause a systemic autoimmune disease similar to human systemic lupus erythematosus. [provided by RefSeq, Dec 2013]