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HMGCS1

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GENERAL INFORMATION

Gene name

 HMGCS1

Gene description

 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)

Protein class

 Enzymes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to the nucleus & cytosol. In addition localized to the plasma membrane.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nucleus (supported), Cytosol (supported)

Additional location

 In addition localized to the Plasma membrane (supported)

Single-cell variation

 Single-cell variation in protein expression observed.

DATA RELIABILITY

Reliability score

 Supported based on 2 antibodies.
HPA036913 , HPA036914
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Mainly localized to the nucleus & cytosol. In addition localized to the plasma membrane.

Main location

 Nucleus (supported), Cytosol (supported)

Additional location

 Plasma membrane (supported)

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA036913 A-431 Nucleoplasm Spatial
Cytosol Spatial
HPA036913 U-2 OS Nucleoplasm
Cytosol
HPA036913 U-251 MG Nucleoplasm
Cytosol
HPA036914 A-431 Nucleus Spatial
Plasma membrane Spatial
Cytosol Spatial
HPA036914 U-2 OS Nucleus Spatial
Plasma membrane Spatial
Cytosol Spatial

GENE INFORMATION

Gene name

 HMGCS1 (HGNC Symbol)

Synonyms

 HMGCS

Description

 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) (HGNC Symbol)

Entrez gene summary

Chromosome

 5

Cytoband

 p12

Chromosome location (bp)

 43289395 - 43313512

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000112972 (version 83.38)

Entrez gene

 3157

UniProt

 Q01581 (UniProt - Evidence at protein level)

neXtProt

 NX_Q01581

Antibodypedia

 HMGCS1 antibodies

PROTEIN BROWSER
HMGCS1-001
HMGCS1-003
HMGCS1-004

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
HMGCS1-001
ENSP00000322706
ENST00000325110
Q01581 [Direct mapping]
Hydroxymethylglutaryl-CoA synthase, cytoplasmic
A0A024R059 [Target identity:100%; Query identity:100%]
3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 (Soluble), isoform CRA_a
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Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001889 [liver development]
GO:0003824 [catalytic activity]
GO:0004421 [hydroxymethylglutaryl-CoA synthase activity]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006629 [lipid metabolic process]
GO:0006695 [cholesterol biosynthetic process]
GO:0007420 [brain development]
GO:0008144 [drug binding]
GO:0008152 [metabolic process]
GO:0008299 [isoprenoid biosynthetic process]
GO:0008584 [male gonad development]
GO:0009645 [response to low light intensity stimulus]
GO:0009725 [response to hormone]
GO:0010033 [response to organic substance]
GO:0010243 [response to organonitrogen compound]
GO:0014070 [response to organic cyclic compound]
GO:0014074 [response to purine-containing compound]
GO:0016853 [isomerase activity]
GO:0033197 [response to vitamin E]
GO:0034698 [response to gonadotropin]
GO:0042493 [response to drug]
GO:0042803 [protein homodimerization activity]
GO:0043177 [organic acid binding]
GO:0044255 [cellular lipid metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0046690 [response to tellurium ion]
GO:0055094 [response to lipoprotein particle]
GO:0070723 [response to cholesterol]
GO:0071372 [cellular response to follicle-stimulating hormone stimulus]
GO:0071397 [cellular response to cholesterol]
GO:0071407 [cellular response to organic cyclic compound]
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 520 aa
57.3 kDa 		No 0
HMGCS1-003
ENSP00000399402
ENST00000433297
Q01581 [Direct mapping]
Hydroxymethylglutaryl-CoA synthase, cytoplasmic
A0A024R059 [Target identity:100%; Query identity:100%]
3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 (Soluble), isoform CRA_a
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0004421 [hydroxymethylglutaryl-CoA synthase activity]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006629 [lipid metabolic process]
GO:0006695 [cholesterol biosynthetic process]
GO:0008152 [metabolic process]
GO:0008299 [isoprenoid biosynthetic process]
GO:0044255 [cellular lipid metabolic process]
GO:0044281 [small molecule metabolic process]
Show all
 520 aa
57.3 kDa 		No 0
HMGCS1-004
ENSP00000427339
ENST00000511774
D6RIW1 [Direct mapping]
Hydroxymethylglutaryl-CoA synthase, cytoplasmic
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0004421 [hydroxymethylglutaryl-CoA synthase activity]
GO:0008152 [metabolic process]
GO:0008299 [isoprenoid biosynthetic process]
Show all
 96 aa
10.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.