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DAP

GENERAL INFORMATION

Gene name

 DAP

Gene description

 Death-associated protein

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in several different tissue types, high levels in lung macrophages.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Pending external verification. Caution, Splice and/or transcript discrepancy exists.

Reliability score

 Uncertain based on 1 antibody.
HPA029456
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 DAP

Synonyms

Description

 Death-associated protein (HGNC Symbol)

Entrez gene summary

 This gene encodes a basic, proline-rich, 15-kD protein. The protein acts as a positive mediator of programmed cell death that is induced by interferon-gamma. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2014]

Chromosome

 5

Cytoband

 p15.2

Chromosome location (bp)

 10679230 - 10761272

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000112977 (version 83.38)

Entrez gene

 1611

UniProt

 P51397 (UniProt - Evidence at protein level)

neXtProt

 NX_P51397

Antibodypedia

 DAP antibodies

PROTEIN BROWSER
DAP-001
DAP-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
DAP-001
ENSP00000230895
ENST00000230895
P51397 [Direct mapping]
Death-associated protein 1
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0006914 [autophagy]
GO:0006915 [apoptotic process]
GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0010507 [negative regulation of autophagy]
GO:0032088 [negative regulation of NF-kappaB transcription factor activity]
GO:0034198 [cellular response to amino acid starvation]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0070513 [death domain binding]
GO:0097190 [apoptotic signaling pathway]
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 102 aa
11.2 kDa 		No 0
DAP-002
ENSP00000394163
ENST00000432074
B4DQ75 [Direct mapping]
Death-associated protein 1; cDNA FLJ55133, weakly similar to Death-associated protein 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 204 aa
23.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.