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BRD8

GENERAL INFORMATION

Gene name

 BRD8

Gene description

 Bromodomain containing 8

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 11
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 General nuclear expression.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 1 antibody.
HPA001841
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Placenta

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 BRD8 (HGNC Symbol)

Synonyms

 p120, SMAP

Description

 Bromodomain containing 8 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene interacts with thyroid hormone receptor in a ligand-dependent manner and enhances thyroid hormone-dependent activation from thyroid response elements. This protein contains a bromodomain and is thought to be a nuclear receptor coactivator. Multiple alternatively spliced transcript variants that encode distinct isoforms have been identified. [provided by RefSeq, Jul 2014]

Chromosome

 5

Cytoband

 q31.2

Chromosome location (bp)

 138139766 - 138178986

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000112983 (version 83.38)

Entrez gene

 10902

UniProt

 Q9H0E9 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9H0E9

Antibodypedia

 BRD8 antibodies

PROTEIN BROWSER
«
BRD8-001
BRD8-002
BRD8-003
BRD8-004
BRD8-005
BRD8-006
BRD8-007
BRD8-013
BRD8-019
BRD8-026
BRD8-201
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
BRD8-001
ENSP00000254900
ENST00000254900
Q9H0E9 [Direct mapping]
Bromodomain-containing protein 8
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000812 [Swr1 complex]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0004887 [thyroid hormone receptor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005739 [mitochondrion]
GO:0006325 [chromatin organization]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0007165 [signal transduction]
GO:0007166 [cell surface receptor signaling pathway]
GO:0030522 [intracellular receptor signaling pathway]
GO:0035267 [NuA4 histone acetyltransferase complex]
GO:0040008 [regulation of growth]
GO:0043967 [histone H4 acetylation]
GO:0043968 [histone H2A acetylation]
Show all
 1235 aa
135.3 kDa 		No 0
BRD8-002
ENSP00000230901
ENST00000230901
Q9H0E9 [Direct mapping]
Bromodomain-containing protein 8
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000812 [Swr1 complex]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0004887 [thyroid hormone receptor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005739 [mitochondrion]
GO:0006325 [chromatin organization]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0007165 [signal transduction]
GO:0007166 [cell surface receptor signaling pathway]
GO:0030522 [intracellular receptor signaling pathway]
GO:0035267 [NuA4 histone acetyltransferase complex]
GO:0040008 [regulation of growth]
GO:0043967 [histone H4 acetylation]
GO:0043968 [histone H2A acetylation]
Show all
 951 aa
102.8 kDa 		No 0
BRD8-003
ENSP00000398067
ENST00000454473
H7C127 [Direct mapping]
Bromodomain-containing protein 8
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005739 [mitochondrion]
Show all
 892 aa
96.8 kDa 		No 0
BRD8-004
ENSP00000398873
ENST00000418329
H7C179 [Direct mapping]
Bromodomain-containing protein 8
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005739 [mitochondrion]
Show all
 861 aa
93.8 kDa 		No 0
BRD8-005
ENSP00000398084
ENST00000441656
H7C128 [Direct mapping]
Bromodomain-containing protein 8
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
 857 aa
93.3 kDa 		No 0
BRD8-006
ENSP00000384845
ENST00000402931
B5MCW3 [Direct mapping]
Bromodomain-containing protein 8
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005739 [mitochondrion]
Show all
 878 aa
95.4 kDa 		No 0
BRD8-007
ENSP00000407414
ENST00000430331
C9JV05 [Direct mapping]
Bromodomain-containing protein 8
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 122 aa
13.3 kDa 		No 0
BRD8-013
ENSP00000407129
ENST00000453824
H7C2P4 [Direct mapping]
Bromodomain-containing protein 8
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 187 aa
20.1 kDa 		No 0
BRD8-019
ENSP00000392646
ENST00000427976
H7C026 [Direct mapping]
Bromodomain-containing protein 8
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
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 336 aa
37.7 kDa 		No 0
BRD8-026
ENSP00000426385
ENST00000511898
H0YA84 [Direct mapping]
Bromodomain-containing protein 8
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005654 [nucleoplasm]
GO:0005739 [mitochondrion]
Show all
 195 aa
21.1 kDa 		No 0
BRD8-201
ENSP00000394330
ENST00000411594
Q9H0E9 [Direct mapping]
Bromodomain-containing protein 8
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000812 [Swr1 complex]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0004887 [thyroid hormone receptor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005739 [mitochondrion]
GO:0006325 [chromatin organization]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0007165 [signal transduction]
GO:0007166 [cell surface receptor signaling pathway]
GO:0030522 [intracellular receptor signaling pathway]
GO:0035267 [NuA4 histone acetyltransferase complex]
GO:0040008 [regulation of growth]
GO:0043967 [histone H4 acetylation]
GO:0043968 [histone H2A acetylation]
Show all
 866 aa
94.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.