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Cancer cells generally displayed moderate cytoplasmic immunoreactivity. A majority of melanomas showed a strong cytoplasmic staining. Most testicular and prostate cancers were weakly stained.
Several cases of melanoma, colorectal, breast, cervical and lung cancer as well a few ovarian and endometrial cancers showed moderate cytoplasmic immunoreactivity. Remaining cancer cells were in general weakly stained or negative.
This gene encodes an integral protein of the inner mitochondrial membrane. The enzyme couples hydride transfer between NAD(H) and NADP(+) to proton translocation across the inner mitochondrial membrane. Under most physiological conditions, the enzyme uses energy from the mitochondrial proton gradient to produce high concentrations of NADPH. The resulting NADPH is used for biosynthesis and in free radical detoxification. Two alternatively spliced variants, encoding the same protein, have been found for this gene. [provided by RefSeq, Jul 2008]
